FBLN2 Protein (AA 1-1184) (His tag)

N° du produit ABIN7505648

Cette protéine Recombinant FBLN2 est exprimée dans HEK-293 Cells.

Aperçu rapide pour FBLN2 Protein (AA 1-1184) (His tag) (ABIN7505648)

Antigène: FBLN2 (Fibulin 2 (FBLN2))

Type de proteíne: Recombinant

Origine: Humain

Source: HEK-293 Cells

Pureté: > 95 % as determined by reducing SDS-PAGE.

Détail du produit

Attributs du protein: AA 1-1184

Purification/Conjugué: Cette FBLN2 protéine est marqué à la His tag.

Séquence: Met1-Leu1184

Attributs du produit: A DNA sequence encoding the Human FBLN2 protein (P98095) (Met1-Leu1184) was expressed with a C-His.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Date de péremption: 12 months

Détail du antigène

Antigène: FBLN2 (Fibulin 2 (FBLN2))

Autre désignation: FBLN2

Sujet:

Abbreviation: FBLN2

Target Synonym: Fibulin-2 (FIBL-2),FBLN2

Background: Fibulin 2 is the second largest member of the seven-member fibulin family of extracellular membrane (ECM) glycoproteins. Fibulin-2 consists of 1184 amino acids (aa) with a predicted molecular weight of ~125 kDa. The overall structure is common to fibulins: 3 Anaphylatoxin (AT)-like domains, 11 Epidermal Growth Factor (EGF)?like domains, and a Fibulin-type carboxy-terminal (FC) domain. Fibulin 2 is considered a Class I fibulin because the 400-residue N-terminus is divided into the Na and Nb sections, with the Na section containing 150-residues and 12 cysteines while the remaining Nb section is cysteine-free. The protein is known to form disulfide-linked homodimers, but it can also be secreted as an oligomer. Fibulin 2 is highly conserved across species, with the human protein sharing 82 % amino acid identity compared to both mouse and rat. Fibulin 2 is considered a multifunctional binding protein due to its association with numerous ECM components, but its specific interactions have yet to be determined. Fibulin 2 is localized at the interface between microfibrils and the elastin core and its known interactions include nidogen-1, perlecan, laminin, aggrecan, endostatins, versican, collagen, and tropoelastin. It is down-regulated in numerous forms of cancer including breast, colorectal, lung, esophageal, and squamous cell carcinoma, but over-expression has been shown with solid tumors. There is also evidence that suggests that Fibulin 2 may play an indirect role in the neurogenesis of adult neural stem cells via interaction with integrins and TGF-beta 1.

Poids moléculaire:

Calculated MW: 130.13 kDa

Observed MW: 130 kDa

UniProt: P98095