IL-25 Protein (His tag)

N° du produit ABIN7520197

Cette protéine Recombinant IL-25 est produite dans HEK-293 Cells.

Aperçu rapide pour IL-25 Protein (His tag) (ABIN7520197)

Antigène: IL-25 (IL25) (Interleukin 25 (IL25))

Type de proteíne: Recombinant

Origine: Souris

Source: HEK-293 Cells

Pureté: > 92 % by SDS-PAGE.

Détail du produit

Purification/Conjugué: Cette IL-25 protéine est marqué à la His tag.

Fonction: Recombinant Mouse IL-17E Protein

Séquence: VSLRIQEGCS HLPSCCPSKE QEPPEEWLKW SSASVSPPEP LSHTHHAESC RASKDGPLNS RAISPWSYEL DRDLNRVPQD LYHARCLCPH CVSLQTGSHM DPLGNSVPLY HNQTVFYRRP CHGEEGTHRR YCLERRLYRV SLACVCVRPR VMA

Specificité: Val 17-Ala 169

Stérilité: 0.22 μm filtered

niveau d'endotoxine: <0.01EU/μg

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Centrifuge the vial before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid votex or vigorously pipetting the protein. For long term storage, it is recommended to add a carrier protein or stablizer (e.g. 0.1 % BSA, 5 % HSA, 10 % FBS or 5 % Trehalose), and aliquot the reconstituted protein solution to minimize free-thaw cycles.

Concentration: 1.05 mg/mL

Buffer: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.

Stock: -20 °C,-80 °C

Stockage commentaire: Store the lyophilized protein at -20°C to -80°C for 12 months.|After reconstitution, the protein solution is stable at -20°C for 3 months, at 2-8°C for up to 1 week.

Détail du antigène

Antigène: IL-25 (IL25) (Interleukin 25 (IL25))

Autre désignation: IL-17E

Sujet:

Description: Interleukin-25 (IL-25) is a cytokine that shares sequence similarity with interleukin 17. This cytokine can induce NF-kappaB activation, and stimulate the production of interleukin 8. Both this cytokine and interleukin 17B are ligands for the cytokine receptor IL17BR. IL-25 is a member of the IL-17 family of cytokines. However, unlike the other members of this family, IL-25 promotes T helper (Th) 2 responses. IL-25 also regulates the development of autoimmune inflammation mediated by IL-17-producing T cells. IL-25 and IL-17, being members of the same cytokine family, play opposing roles in the pathogenesis of organ-specific autoimmunity. IL-25 promotes cell expansion and Th2 cytokine production when Th2 central memory cells are stimulated with thymic stromal lymphopoietin (TSLP)-activated dendritic cells (DCs), homeostatic cytokines, or T cell receptor for antigen triggering. Elevated expression of IL-25 and IL-25R transcripts was observed in asthmatic lung tissues and atopic dermatitis skin lesions, linking their possible roles with exacerbated allergic disorders. A plausible explanation that IL-25 produced by innate effector eosinophils and basophils may augment the allergic inflammation by enhancing the maintenance and functions of adaptive Th2 memory cells had been provided.

Name: IL-25, Il17e, IL-17e

ID gène: 140806

UniProt: Q8VHH8