TFCP2L1 Protein (AA 1-479) (His tag)

N° du produit ABIN7557247

Cette protéine Recombinant TFCP2L1 est produite dans HEK-293 Cells.

Aperçu rapide pour TFCP2L1 Protein (AA 1-479) (His tag) (ABIN7557247)

Antigène: TFCP2L1 (Transcription Factor CP2-Like 1 (TFCP2L1))

Type de proteíne: Recombinant

Origine: Souris

Source: HEK-293 Cells

Pureté: > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)

Classe de qualité: custom-made

Détail du produit

Attributs du protein: AA 1-479

Purification/Conjugué: Cette TFCP2L1 protéine est marqué à la His tag.

Fonction: Predefined custom protein recombinant Tfcp2l1 Protein expressed in mammalian cells.

Séquence: MLFWHTQPEH YNQHNSGSYL RDVLALPIFK QEEPQLSPEN GARLPPLQYV LCAATSPAVK LHEETLTYLN QGQSYEIRLL ENRKLGDFQD LNTKYVKSII RVVFHDRRLQ YTEYQQLEGW RWSRPGDRIL DIDIPLSVGI LDPRASPTQL NAVEFLWDPS KRASAFIQVH CISTEFTPRK HGGEKGVPFR VQIDTFKQNE SGDYSEHLHS ASCQIKVFKP KGADRKQKTD REKMEKRTAQ EKEKYQPSYE TTILTECSPW PDVPYQANNT PSPSYNGSPN SFGLREGNSS PNHPVEPLPL GSDHLLPSAS IQDAQQWLHR NRFSQFCWLF ASFSGADLLK MSRDDLVQVC GPADGIRLFN AIKGRNVRPK MTIYVCQELE QNQLPLPQKQ DDSGDNSLCV YHAIFLEELT TLELTEKIAS LYSIPPQHIH RVYRQGPAGI HVVVSNEMVQ NFQDESCFIL STLKAESNDG YHIILKCGL Sequence without tag. The proposed Strep-Tag is based on experience with the expression system. Our team may suggest an additional tag depending on the complexity of the protein. If you have a special request, please contact us.

Specificité: If you are looking for a specific domain and are interested in a partial protein or a different isoform, please contact us regarding an individual offer.

Attributs du produit: Key Benefits:

• Predefined custom protein - from design to production - by highly experienced protein experts.
• Protein expressed in mammalian cells and purified in one-step affinity chromatography
• The optimized expression system ensures reliability for intracellular, secreted and transmembrane proteins.
• State-of-the-art algorithm used for plasmid design (Gene synthesis).

This protein is a predefined protein and will be made for the first time for your order. Our experts in the lab try to ensure that you receive soluble protein.

If you are not interested in a full length protein, please contact us for individual protein fragments.

The big advantage of ordering our predefined custom proteins in comparison to ordering custom-made proteins from other companies is that there is no financial obligation in case the protein cannot be expressed or purified.

Information d'application

Indications d'application: We expect the protein to work for functional studies. As the protein has not been tested for functional studies yet we cannot offer a guarantee though.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: The buffer composition is at the discretion of the manufacturer.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -80 °C

Stockage commentaire: Store at -80°C.

Date de péremption: 12 months

Détail du antigène

Antigène: TFCP2L1 (Transcription Factor CP2-Like 1 (TFCP2L1))

Autre désignation: Tfcp2l1

Sujet: Transcription factor CP2-like protein 1 (CP2-related transcriptional repressor 1) (CRTR-1),FUNCTION: Transcription factor that facilitates establishment and maintenance of pluripotency in embryonic stem cells (ESCs) (PubMed:23942233, PubMed:26321140). With Klf2, acts as the major effector of self-renewal that mediates induction of pluripotency downstream of LIF/Stat3 and Wnt/beta-catenin signaling (PubMed:23942238, PubMed:23942233, PubMed:26321140). Required for normal duct development in the salivary gland and kidney (PubMed:17079272). Coordinates the development of the kidney collecting ducts intercalated (IC) and principal (PC) cells, which regulate acid-base and salt-water homeostasis, respectively (PubMed:28577314). Regulates the expression of IC genes including subunits B1 and D2 of the V-ATPase complex, Oxgr1, Ca12, Slc4a1, Aqp6 and IC-specific transcription factor Foxi1 (PubMed:28577314). Regulates also the expression of Jag1 and subsequent notch signaling in the collecting duct (PubMed:28577314). Jag1 initiates notch signaling in PCs but inhibits notch signaling in ICs (PubMed:28577314). Acts as a transcriptional suppressor that may suppress UBP1-mediated transcriptional activation (PubMed:11073954). Modulates the placental expression of CYP11A1 (By similarity). {ECO:0000250|UniProtKB:Q9NZI6, ECO:0000269|PubMed:11073954, ECO:0000269|PubMed:17079272, ECO:0000269|PubMed:23942233, ECO:0000269|PubMed:23942238, ECO:0000269|PubMed:26321140, ECO:0000269|PubMed:28577314}.

Poids moléculaire: 54.7 kDa

UniProt: Q3UNW5

AlphaFold: Q3UNW5