SLCO1A5 Protein (AA 1-670) (His tag)

N° du produit ABIN7560126

Protéine Recombinant SLCO1A5 exprimée dans HEK-293 Cells.

Aperçu rapide pour SLCO1A5 Protein (AA 1-670) (His tag) (ABIN7560126)

Antigène: SLCO1A5 (Solute Carrier Organic Anion Transporter Family, Member 1a5 (SLCO1A5))

Type de proteíne: Recombinant

Origine: Souris

Source: HEK-293 Cells

Pureté: > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)

Classe de qualité: custom-made

Détail du produit

Attributs du protein: AA 1-670

Purification/Conjugué: Cette SLCO1A5 protéine est marqué à la His tag.

Fonction: Predefined custom protein recombinant Slco1a5 Protein expressed in mammalian cells.

Séquence: MGETEKRIAT HGVRCFSKIK MFLLALTCAY VSKSLSGIYM NSMLTQIERQ FDIPTSIVGL INGSFEIGNL LLIILVSYFG TKLHRPIMIG IGCVIMGLGC FLMSLPHFLM GRYEYETTIS PTSNLSSNSF LCMENRTQTL KPTQDPAECV KEMKSLMWIY VLVGNIIRGI GETPIMPLGI SYIEDFAKSE NSPLYIGILE SGKMIGPIVG LLLGSFCARI YVDTGSVNTD DLTITPTDTR WVGAWWIGFL VCAGVNILTS IPFFFFPKTL PKEGLQDNVA RTENDKEEKH REKAKEENRG ITKDFLPFMK SLSCNPIYML LILTSVLQIN AFINMFTFLP KYLEQQYGKS TSEVVLLIGV CNLPPICIGY LLIGFIMKKF RITVKKAAYM AFCLSLFEYL LSYFHFMISC DNFQVAGLTT SYEGVQHPLY VENKVLADCN TRCSCLTNTW DPVCGDNGLS YMSACLAGCE KSVGMGTHMV FQNCSCIQSS GNSSAVLGLC KKGPECANKL QYFLIMSVIG SFIYSITAIP GYMVLLRCIK SEEKSLGIGL HAFCTRIFAG IPAPIYFGAL IDRTCLHWGT LKCGEPGACR IYNINNFRRI YLVLPAALRG SSYLPAFFIL ILMRKFQLPG EMYSSETELA DMKQTVKKSE CTDVHGIPKV ENDGELKTKL Sequence without tag. The proposed Strep-Tag is based on experience with the expression system. Our team may suggest an additional tag depending on the complexity of the protein. If you have a special request, please contact us.

Specificité: If you are looking for a specific domain and are interested in a partial protein or a different isoform, please contact us regarding an individual offer.

Attributs du produit: Key Benefits:

• Predefined custom protein - from design to production - by highly experienced protein experts.
• Protein expressed in mammalian cells and purified in one-step affinity chromatography
• The optimized expression system ensures reliability for intracellular, secreted and transmembrane proteins.
• State-of-the-art algorithm used for plasmid design (Gene synthesis).

This protein is a predefined protein and will be made for the first time for your order. Our experts in the lab try to ensure that you receive soluble protein.

If you are not interested in a full length protein, please contact us for individual protein fragments.

The big advantage of ordering our predefined custom proteins in comparison to ordering custom-made proteins from other companies is that there is no financial obligation in case the protein cannot be expressed or purified.

Information d'application

Indications d'application: We expect the protein to work for functional studies. As the protein has not been tested for functional studies yet we cannot offer a guarantee though.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: The buffer composition is at the discretion of the manufacturer.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -80 °C

Stockage commentaire: Store at -80°C.

Date de péremption: 12 months

Détail du antigène

Antigène: SLCO1A5 (Solute Carrier Organic Anion Transporter Family, Member 1a5 (SLCO1A5))

Autre désignation: Slco1a5

Sujet: Solute carrier organic anion transporter family member 1A5 (Organic anion-transporting polypeptide 3) (OATP-3) (Sodium-independent organic anion transporter 3) (Solute carrier family 21 member 7),FUNCTION: Na(+)-independent transporter that mediates the cellular uptake of a broad range of organic anions such as the endogenous bile salts cholate and deoxycholate, either in their unconjugated or conjugated forms (taurocholate and glycocholate), estrone 3-sulfate and prostaglandin E2, at the plasma membrane. Responsible for intestinal absorption of bile acids. Capable of thyroid hormone transport (both T3 or 3,3',5'-triiodo-L-thyronine, and T4 or L-tyroxine) (By similarity). Plays roles in blood-brain and -cerebrospinal fluid barrier transport of organic anions and signal mediators, and in hormone uptake by neural cells (PubMed:15255953). May also play a role in the reuptake of neuropeptides such as substance P/TAC1 and vasoactive intestinal peptide/VIP released from retinal neurons (By similarity). Shows a  pH -sensitive substrate specificity which may be ascribed to the protonation state of the binding site and leads to a stimulation of substrate transport in an acidic microenvironment. Hydrogencarbonate/HCO3(-) acts as the probable counteranion that exchanges for organic anions (By similarity). May contribute to regulate the transport of organic compounds in testis across the blood-testis-barrier (By similarity). {ECO:0000250|UniProtKB:O88397, ECO:0000250|UniProtKB:P46721, ECO:0000303|PubMed:15255953}.

Poids moléculaire: 74.7 kDa

UniProt: Q91YY5

AlphaFold: Q91YY5