Majin (AA 1-256) protein (His tag)

N° du produit ABIN7561158

Protéine Recombinant Majin exprimée dans HEK-293 Cells.

Aperçu rapide pour Majin (AA 1-256) protein (His tag) (ABIN7561158)

Antigène: Majin

Type de proteíne: Recombinant

Origine: Souris

Source: HEK-293 Cells

Pureté: > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)

Classe de qualité: custom-made

Détail du produit

Attributs du protein: AA 1-256

Purification/Conjugué: His tag

Fonction: Predefined custom protein recombinant Majin Protein expressed in mammalian cells.

Séquence: MSLKPFTYPF PETRFLHAGP NVYKFKIRYG NSIRGEEIED KEVIVQELED SIRAVLANMD SLQPFVTEHF IVFPYKSKWE RVSHLKFKHG ESILTPYPFV FTLYIEMKWF AEDLPSGKPA DDIPLELVLA ETEAEEATMR KWKRKLMEEP SSPSRQGPHR AKMETSSEAS SNKKPLKESK RSTDEEAQQE YQDTPASNAI AVKEQDAALG HGLQGLVVPP LQHSSPPPPK EPGARGFLGF LSALFPFRYF FKKSGQ Sequence without tag. The proposed Strep-Tag is based on experience with the expression system. Our team may suggest an additional tag depending on the complexity of the protein. If you have a special request, please contact us.

Specificité: If you are looking for a specific domain and are interested in a partial protein or a different isoform, please contact us regarding an individual offer.

Attributs du produit: Key Benefits:

• Predefined custom protein - from design to production - by highly experienced protein experts.
• Protein expressed in mammalian cells and purified in one-step affinity chromatography
• The optimized expression system ensures reliability for intracellular, secreted and transmembrane proteins.
• State-of-the-art algorithm used for plasmid design (Gene synthesis).

This protein is a predefined protein and will be made for the first time for your order. Our experts in the lab try to ensure that you receive soluble protein.

If you are not interested in a full length protein, please contact us for individual protein fragments.

The big advantage of ordering our predefined custom proteins in comparison to ordering custom-made proteins from other companies is that there is no financial obligation in case the protein cannot be expressed or purified.

Information d'application

Indications d'application: We expect the protein to work for functional studies. As the protein has not been tested for functional studies yet we cannot offer a guarantee though.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: The buffer composition is at the discretion of the manufacturer.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -80 °C

Stockage commentaire: Store at -80°C.

Date de péremption: 12 months

Détail du antigène

Antigène: Majin

Sujet: Membrane-anchored junction protein,FUNCTION: Meiosis-specific telomere-associated protein involved in meiotic telomere attachment to the nucleus inner membrane, a crucial step for homologous pairing and synapsis. Component of the MAJIN-TERB1-TERB2 complex, which promotes telomere cap exchange by mediating attachment of telomeric DNA to the inner nuclear membrane and replacement of the protective cap of telomeric chromosomes: in early meiosis, the MAJIN-TERB1-TERB2 complex associates with telomeric DNA and the shelterin/telosome complex. During prophase, the complex matures and promotes release of the shelterin/telosome complex from telomeric DNA. In the complex, MAJIN acts as the anchoring subunit to the nucleus inner membrane. MAJIN shows DNA-binding activity, possibly for the stabilization of telomere attachment on the nucleus inner membrane. {ECO:0000269|PubMed:26548954}.

Poids moléculaire: 29.2 kDa

UniProt: Q9D992

AlphaFold: Q9D992