CLDN18.2 protein (DYKDDDDK Tag,Strep Tag)

N° du produit ABIN7596492

Protéine Synthetic Nanodisc exprimée dans HEK-293 Cells.

Aperçu rapide pour CLDN18.2 protein (DYKDDDDK Tag,Strep Tag) (ABIN7596492)

Antigène: CLDN18.2

Type de proteíne: Synthetic Nanodisc

Origine: Humain

Source: HEK-293 Cells

Application: Cryogenic electron microscopy (cryo-EM), ELISA, Immunogen (Imm), Phage Display (PhD), Surface Plasmon Resonance (SPR)

Détail du produit

Purification/Conjugué: DYKDDDDK Tag,Strep Tag

Fonction: Human CLDN18.2-Strep full length protein-synthetic nanodisc

Information d'application

Commentaires:

Advantages:

• Highly purified membrane proteins
• High solubility in aqueous solutions
• High stability
• Proteins are in a native membrane environment and remain biologically active
• No detergent and can be used for cell-based assays
• No MSP backbone proteins
• Mammalian cell expression system ensures post- translational modifications

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: Solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization.

Stock: -20 °C,-80 °C

Stockage commentaire: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Date de péremption: 12 months

Détail du antigène

Antigène: CLDN18.2

Sujet: SFTA5, SFTPJ
A member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is upregulated in patients with ulcerative colitis and highly overexpressed in infiltrating ductal adenocarcinomas. PKC/MAPK/AP-1 (protein kinase C/mitogen-activated protein kinase/activator protein-1) dependent pathway regulates the expression of this gene in gastric cells. Alternatively spliced transcript variants encoding different isoforms have been identified.

Poids moléculaire: The human full length CLDN18.2-Strep Protein has a MW of 27.5 kDa

UniProt: P56856