Cathepsin L Protein (His tag)

N° du produit ABIN7794657

Cette protéine Recombinant Cathepsin L est produite dans HEK-293 Cells.

Aperçu rapide pour Cathepsin L Protein (His tag) (ABIN7794657)

Antigène: Cathepsin L (CTSL1) (Cathepsin L1 (CTSL1))

Type de proteíne: Recombinant

Origine: Humain

Source: HEK-293 Cells

Pureté: The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.

Détail du produit

Purification/Conjugué: Cette Cathepsin L protéine est marqué à la His tag.

Fonction: Recombinant human CTSL Protein with C-terminal 10?His tag

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Stock: -20 °C,-80 °C

Stockage commentaire: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Détail du antigène

Antigène: Cathepsin L (CTSL1) (Cathepsin L1 (CTSL1))

Autre désignation: CTSL

Sujet: MEP, CATL, CTSL1 Background: The protein encoded by this gene is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. The encoded protein has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. This protein, which is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor. Additionally, this protein cleaves the S1 subunit of the SARS-CoV-2 spike protein, which is necessary for entry of the virus into the cell. [provided by RefSeq, Aug 2020]

Poids moléculaire: Predicted: 37.2 kDa after removal of the signal peptide. The apparent molecular mass of CTSL-His is approximately 35-55 kDa due to glycosylation.

UniProt: P07711

Pathways: Activation of Innate immune Response, Toll-Like Receptors Cascades