PLA2G7 Protéine

N° du produit ABIN7849665

Protéine Recombinant PLA2G7 exprimée dans Escherichia coli (E. coli).

Aperçu rapide pour PLA2G7 Protéine (ABIN7849665)

Antigène: PLA2G7 (Lp-PLA2) (Lipoprotein-Associated phospholipase A2 (Lp-PLA2))

Type de proteíne: Recombinant

Origine: Humain

Source: Escherichia coli (E. coli)

Application: ELISA

Pureté: >90 % by SDS-PAGE

Détail du produit

Fonction: Recombinant Human Lipoprotein-associated phospholipase A2, Lp-PLA2 Protein

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: 10 mM Tris-Hcl, pH 10.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Ship at 4°C. Upon receipt, aliquot and store at -20°C or -80°C for long term. Avoid repeated freeze and thaw cycles.

Détail du antigène

Antigène: PLA2G7 (Lp-PLA2) (Lipoprotein-Associated phospholipase A2 (Lp-PLA2))

Autre désignation: Lp-PLA2

Sujet:

Synonyms: PLA2G7, LDL-PLA2, LP-PLA2, PAFAD, PAFAH, PAF-AH, Lipoprotein-associated phospholipase A2, phospholipase A2 group VII, gVIIA-PLA2, PAF acetylhydrolase

Description: Recombinant human LpPLA2 protein with his tag with molecular weight of 65.6 kDa.

Background: Lipoprotein-associated phospholipase A2 (Lp-PLA2) also known as platelet-activating factor acetylhydrolase (PAF-AH) is a phospholipase A2 enzyme that in humans is encoded by the PLA2G7 gene. Both LpPLA2 mass and activity were found within low-density lipoprotein (LDL) and HDL pools with more LpPLA2 mass being associated with HDL (54 % vs 44 %, P-value <.001) and more LpPLA2 activity being associated with LDL (56 % vs 40 %, P value = .02). In T1D, more LpPLA2 activity was associated with large- or less-dense LDL compared to those without diabetes. However, no difference in LpPLA2 activity or mass between lipoprotein subfractions was observed between all groups, and there was no relationship between LpPLA2 activity or mass and its distribution and CAC score progression in healthy or T1D men.LpPLA2 is found in both LDL and HDL and is distributed differently in men with T1D without any relationship to CAC score progression.

Pathways: Peptide Hormone Metabolism