FAM131B-BRAF (Active) protein (GST tag)

N° du produit ABIN7856311

Cette protéine Recombinant FAM131B-BRAF est exprimée dans Baculovirus infected Insect Cells.

Aperçu rapide pour FAM131B-BRAF (Active) protein (GST tag) (ABIN7856311)

Antigène: FAM131B-BRAF

Type de proteíne: Recombinant

Activité biologique: Active

Origine: Humain

Source: Baculovirus infected Insect Cells

Application: Kinase Activity Assay (KAA)

Détail du produit

Purification/Conjugué: GST tag

Fonction: Recombinant FAM131B-BRAF (Fex2Bex9), Active

Séquence: FAB131B (1-30 exon2)-BRAF (381-end or exon9-18)

Attributs du produit: Recombinant human fusion FAB131B (1-30 exon2)-BRAF (381-end or exon9-18) protein was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Stérilité: Sterile

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Supplied as sterile 50 mM Tris-HCl, pH 7.5, 50-300 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25-1.0 mM DTT, 0-0.1 mM PMSF, 10-25 % glycerol

Agent conservateur: Dithiothreitol (DTT), PMSF

Précaution d'utilisation: This product contains Dithiothreitol (DTT): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -80 °C

Stockage commentaire: Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. Product shipped on dry ice.

Date de péremption: 12 months

Détail du antigène

Antigène: FAM131B-BRAF

Sub Type: Fusionprotein

Sujet: KIAA1549-BRAF is a gene fusion resulting from a tandem duplication event involving the BRAF kinase gene that have recently been identified as the most frequent genetic alteration in many cancers. The KIAA1549-BRAF fusion typically results from a 2.0 Mb tandem duplication in chromosome band 7q34. The KIAA1549:BRAF fusion gene is considered a driver genetic event in pilocytic astrocytoma and many other pediatric brain neoplasms. KIAA1549-BRAF fusion gene and BRAF (V600E) mutation may be responsible for deregulation of the Ras-RAF-ERK signaling pathway in many brain cancers.

Poids moléculaire: ~75 kDa

NCBI Accession: NM_004333