ACE2 Protein (AA 18-740)

N° du produit ABIN7938599

Protéine Recombinant ACE2 exprimée dans Baculovirus infected Insect Cells.

Aperçu rapide pour ACE2 Protein (AA 18-740) (ABIN7938599)

Antigène: ACE2 (Angiotensin I Converting Enzyme 2 (ACE2))

Type de proteíne: Recombinant

Origine: Humain

Source: Baculovirus infected Insect Cells

Application: Functional Studies (Func), Screening Assay (ScA), Activity Assay (AcA)

Détail du produit

Attributs du protein: AA 18-740

Fonction: Recombinant ACE2 (18-740) protein

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Recombinant ACE2 (18-740) protein is supplied in 25 mM HEPES-NaOH pH 7.5, 300 mM NaCl, 10 % glycerol, 0.04 % Triton X-100, and 0.5 mM TCEP.

Conseil sur la manipulation: Avoid repeated freeze/thaw cycles,keep on ice when not in storage

Stock: -80 °C

Stockage commentaire: Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

Détail du antigène

Antigène: ACE2 (Angiotensin I Converting Enzyme 2 (ACE2))

Autre désignation: ACE2

Sujet:

Protein Background: ACE2 (Angiotensin I Converting Enzyme 2) belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases, it is a critical regulator of blood volume, systemic vascular resistance, and thus cardiovascular homeostasis. This protein catalyzes the cleavage of angiotensin I to angiotensin 1-9, a nine-amino acid peptide with anti-hypertrophic effects in cardiomyocytes, and angiotensin II to the vasodilator angiotensin 1-7, which acts as a beneficial vasodilator and anti-proliferation agent, counterbalancing the actions of the vasoconstrictor angiotensin II. ACE2 removes the C-terminal residue from three other vasoactive peptides, neurotensin, kinetensin, and des-Arg bradykinin, but is not active on bradykinin. Also cleaves other biological peptides, such as apelins (apelin-13, [Pyr1] apelin-13, apelin-17, apelin-36), casomorphins (beta-casomorphin-7, neocasomorphin) and dynorphin A with high efficiency. In addition, ACE2 C-terminus is homologous to collectrin and is responsible for the trafficking of the neutral amino acid transporter SL6A19 to the plasma membrane of gut epithelial cells via direct interaction, regulating its expression on the cell surface and its catalytic activity.

Short Description: Recombinant ACE2 (18-740) protein that includes amino acids 18-740 of human ACE2 protein (accession number NP_001358344.1) was expressed in a baculovirus expression system, and contains a C-terminal FLAG tag. The molecular weight of the protein is 85.4 kDa.

Pathways: ACE Inhibitor Pathway, Peptide Hormone Metabolism, Regulation of Systemic Arterial Blood Pressure by Hormones, Feeding Behaviour