beta Catenin Protéine

N° du produit ABIN7938678

Cette protéine Recombinant beta Catenin est produite dans Baculovirus infected Insect Cells.

Aperçu rapide pour beta Catenin Protéine (ABIN7938678)

Antigène: beta Catenin (CATNB) (Catenin, beta (CATNB))

Type de proteíne: Recombinant

Origine: Humain

Source: Baculovirus infected Insect Cells

Application: Activity Assay (AcA), Functional Studies (Func), Screening Assay (ScA)

Détail du produit

Fonction: Recombinant beta-Catenin protein

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Recombinant beta-Catenin protein is supplied in 25 mM HEPES pH 7.5, 300 mM NaCl, 20 % glycerol, 0.04 % Triton X-100, 0.5 mM TCEP.

Conseil sur la manipulation: Avoid repeated freeze/thaw cycles,keep on ice when not in storage

Stock: -80 °C

Stockage commentaire: Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

Détail du antigène

Antigène: beta Catenin (CATNB) (Catenin, beta (CATNB))

Autre désignation: beta-Catenin

Sujet:

Protein Background: beta-Catenin is a key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes.

Short Description: Recombinant beta-Catenin protein was expressed in a baculovirus expression system as the full-length protein (accession number NP_001091679.1) with an N-terminal FLAG tag. The molecular weight of beta-Catenin is 86.79 kDa.

Aliases: CTNNB1, catenin beta 1, armadillo, CTNNB, NEDSDV, MRD19, EVR7

Pathways: Peptide Hormone Metabolism