EIF4A2 Protéine

N° du produit ABIN7938832

Cette protéine Recombinant EIF4A2 est exprimée dans Escherichia coli (E. coli).

Aperçu rapide pour EIF4A2 Protéine (ABIN7938832)

Antigène: EIF4A2 (Eukaryotic Translation Initiation Factor 4A2 (EIF4A2))

Type de proteíne: Recombinant

Origine: Humain

Source: Escherichia coli (E. coli)

Application: Activity Assay (AcA), Functional Studies (Func), Screening Assay (ScA)

Détail du produit

Fonction: Recombinant EIF4A2 protein

Attributs du produit: EIF4A2 (Eukaryotic Translation Initiation Factor 4A, Isoform 2), also called EIF4F or DDX2B, is an ATP dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition. It is required for mRNA binding to the ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon. This protein is involved in the binding of mRNA to 40S subunit of ribosome, ubiquitous with high expression in skeletal muscle and ovary. Diseases associated with EIF4A2 include Retinitis Pigmentosa 29 and X-Linked Hereditary Ataxia. Among its related pathways are the TGFb pathway and Apoptotic pathways in Synovial Fibroblasts.

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Recombinant EIF4A2 protein is supplied in 25 mM Tris-HCl pH 8.0, 500 mM NaCl, 10 % glycerol, and 0.5 mM TCEP.

Conseil sur la manipulation: Avoid repeated freeze/thaw cycles,keep on ice when not in storage

Stock: -80 °C

Stockage commentaire: Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

Détail du antigène

Antigène: EIF4A2 (Eukaryotic Translation Initiation Factor 4A2 (EIF4A2))

Autre désignation: EIF4A2

Sujet:

Protein Background: EIF4A2 (Eukaryotic Translation Initiation Factor 4A, Isoform 2), also called EIF4F or DDX2B, is an ATP dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition. It is required for mRNA binding to the ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon. This protein is involved in the binding of mRNA to 40S subunit of ribosome,ubiquitous with high expression in skeletal muscle and ovary. Diseases associated with EIF4A2 include Retinitis Pigmentosa 29 and X-Linked Hereditary Ataxia. Among its related pathways are the TGFb pathway and Apoptotic pathways in Synovial Fibroblasts.

Short Description: Recombinant EIF4A2 protein was expressed in E.coli as the full length protein (accession number NP_001958.2) with an N-terminal 6xHis Tag. The molecular weight of the protein is 49.9 kDa.

Aliases: Eukaryotic Translation Initiation Factor 4A2, DDX2B