PRDM16 Protéine

N° du produit ABIN7939440

Cette protéine Recombinant PRDM16 est exprimée dans Baculovirus infected Insect Cells.

Aperçu rapide pour PRDM16 Protéine (ABIN7939440)

Antigène: PRDM16 (PR Domain Containing 16 (PRDM16))

Type de proteíne: Recombinant

Origine: Humain

Source: Baculovirus infected Insect Cells

Application: Activity Assay (AcA), Functional Studies (Func), Screening Assay (ScA)

Détail du produit

Fonction: Recombinant PRDM16 protein

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Recombinant PRDM16 protein is supplied in 25 mM HEPES pH 7.5, 300 mM NaCl, 20 % glycerol, 0.04 % Triton X-100, 0.5 mM TCEP.

Conseil sur la manipulation: Avoid repeated freeze/thaw cycles,keep on ice when not in storage

Stock: -80 °C

Stockage commentaire: Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

Détail du antigène

Antigène: PRDM16 (PR Domain Containing 16 (PRDM16))

Autre désignation: PRDM16

Sujet:

Protein Background: PRDM16 (Histone-lysine N-methyltransferase PRDM16), also known as CMD1LL, KMT8F, LVNC8, MEL1 and PFM13. PRDM16 was found in t(1,3)(p36,q21)-positive AML, which has similar clinicopathological features to3q21q26 syndrome, as a transcriptionally activated gene near the chromosomal breakpoint. The structure of the PRDM16 gene product is very similar to that of MDS1/EVI1. Both products have the PRdomain at the amino-terminus, 2 separated DNA binding domains with 7 and 3 tandem zinc finger repeats, CtBP-binding motifs, and other possible transcriptional regulatory domains. By similarity, PRDM16 probably catalyzes the monomethylation of free histone H3 in the cytoplasm which is then transported to the nucleus and incorporated into nucleosomes where SUV39H methyltransferases use it as a substrate to catalyze histone H3 'Lys-9' trimethylation.

Short Description: Recombinant PRDM16 protein was expressed in a baculovirus expression system as the full length protein (accession number NP_071397.3) with an N-terminal FLAG tag. The molecular weight of the protein is 141.5 kDa.

Aliases: Transcription Factor MEL1, KMT8F, Histone-Lysine N-methyltransferase PRDM16, CMD1LL, KMT8F, LVNC8, MEL1, PFM13

Pathways: Stem Cell Maintenance, Brown Fat Cell Differentiation