SMAD1 Protéine

N° du produit ABIN7939586

Protéine Recombinant SMAD1 exprimée dans Baculovirus infected Insect Cells.

Aperçu rapide pour SMAD1 Protéine (ABIN7939586)

Antigène: SMAD1 (SMAD, Mothers Against DPP Homolog 1 (SMAD1))

Type de proteíne: Recombinant

Origine: Humain

Source: Baculovirus infected Insect Cells

Application: Activity Assay (AcA), Functional Studies (Func), Screening Assay (ScA)

Détail du produit

Fonction: Recombinant SMAD1 protein

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Recombinant SMAD1 protein is supplied in 25 mM HEPES pH 7.5, 300 mM NaCl, 20 % glycerol, 0.04 % Triton X-100, 0.5 mM TCEP.

Conseil sur la manipulation: Avoid repeated freeze/thaw cycles,keep on ice when not in storage

Stock: -80 °C

Stockage commentaire: Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

Détail du antigène

Antigène: SMAD1 (SMAD, Mothers Against DPP Homolog 1 (SMAD1))

Autre désignation: SMAD1

Sujet:

Protein Background: SMAD1 is a transcriptional modulator that plays a role in various cellular processes, including embryonic development, cell differentiation, and tissue homeostasis. Upon BMP ligand binding to their receptors at the cell surface, is phosphorylated by activated type I BMP receptors (BMPRIs) and associates with SMAD1 to form a heteromeric complex which translocates into the nucleus acting as transcription factor. In turn, the hetero-trimeric complex recognizes cis-regulatory elements containing Smad Binding Elements (SBEs) to modulate the outcome of the signaling network.

Short Description: Recombinant SMAD1 protein was expressed in a baculovirus expression system as the full length protein (accession number NP_005891.1) with an N-terminal FLAG tag. The molecular weight of SMAD1 is 53.53 kDa.

Aliases: JV4-1, MADH1, BSP-1, Mothers Against Decapentaplegic Homolog 1

Pathways: Stem Cell Maintenance, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development