STUB1 Protéine

N° du produit ABIN7939612

Protéine Recombinant STUB1 exprimée dans Escherichia coli (E. coli).

Aperçu rapide pour STUB1 Protéine (ABIN7939612)

Antigène: STUB1 (STIP1 Homology and U-Box Containing Protein 1 (STUB1))

Type de proteíne: Recombinant

Origine: Humain

Source: Escherichia coli (E. coli)

Application: Activity Assay (AcA), Functional Studies (Func), Screening Assay (ScA)

Détail du produit

Fonction: Recombinant STUB1 / CHIP protein

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Recombinant STUB1 / CHIP protein is supplied in 25 mM Tris 8.0, 300 mM NaCl, 20 % glycerol, 0.5 mM TCEP.

Conseil sur la manipulation: Avoid repeated freeze/thaw cycles,keep on ice when not in storage

Stock: -80 °C

Stockage commentaire: Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

Détail du antigène

Antigène: STUB1 (STIP1 Homology and U-Box Containing Protein 1 (STUB1))

Autre désignation: STUB1 & CHIP

Sujet:

Protein Background: STUB1 (E3 ubiquitin-protein ligase CHIP) also known as CHIP, HSPABP2, NY-CO-7, SCA48, SCAR16, SDCCAG7 and UBOX1. STUB1 is a E3 ubiquitin-protein ligase which targets misfolded chaperone substrates towards proteasomal degradation. Ubiquitinates ICER-type isoforms of CREM and targets them for proteasomal degradation, thereby acts as a positive effector of MAPK/ERK-mediated inhibition of apoptosis in cardiomyocytes. Inhibits lipopolysaccharide-induced apoptosis and hypertrophy in cardiomyocytes, via ubiquitination and subsequent proteasomal degradation of NFATC3. Collaborates with ATXN3 in the degradation of misfolded chaperone substrates: ATXN3 restricting the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension. Ubiquitinates NOS1 in concert with Hsp70 and Hsp40. Modulates the activity of several chaperone complexes, including Hsp70, Hsc70 and Hsp90.

Short Description: Recombinant STUB1 / CHIP protein that includes full length of human STUB1 protein (accession number NP_005852.2) was expressed in E. coli and contains an N-terminal His tag with a molecular weight of 37.02 kDa. The purity of the protein is ≥ 95 % by SDS-PAGE.

Aliases: CHIP, SDCCAG7, UBOX1, E3 Ubiquitin Protein Ligase CHIP, HSPABP2, NY-CO-7, SCAR16, SDCCAG7

Pathways: Regulation of Hormone Metabolic Process, Response to Water Deprivation