UBA7 Protéine

N° du produit ABIN7939725

Cette protéine Recombinant UBA7 est produite dans Baculovirus infected Insect Cells.

Aperçu rapide pour UBA7 Protéine (ABIN7939725)

Antigène: UBA7 (Ubiquitin-Like Modifier Activating Enzyme 7 (UBA7))

Type de proteíne: Recombinant

Origine: Humain

Source: Baculovirus infected Insect Cells

Application: Activity Assay (AcA), Functional Studies (Func), Screening Assay (ScA)

Détail du produit

Fonction: Recombinant UBA7 (UBE1L) protein

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Recombinant UBA7 (UBE1L) protein is supplied in 25 mM HEPES pH 7.5, 300 mM NaCl, 20 % glycerol, 0.04 % Triton X-100, 0.5 mM TCEP.

Conseil sur la manipulation: Avoid repeated freeze/thaw cycles,keep on ice when not in storage

Stock: -80 °C

Stockage commentaire: Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

Détail du antigène

Antigène: UBA7 (Ubiquitin-Like Modifier Activating Enzyme 7 (UBA7))

Autre désignation: UBA7

Sujet:

Protein Background: UBA7 is an E1-activating enzyme that catalyzes the covalent conjugation of the ubiquitin-like protein product of ISG15 to additional interferon stimulated proteins (ISGs) as well as other cellular proteins such as P53 in a process termed protein ISGylation. Plays an essential role in antiviral immunity together with ISG15 by restricting the replication of many viruses including rabies virus, influenza virus, sindbis virus, rotavirus or human cytomegalovirus. For example, ISG15 modification of influenza A protein NS1 disrupts the association of the NS1 with importin-alpha leading to NS1 nuclear import inhibition. ISGylation of human cytomegalovirs protein UL26 regulates its stability and inhibits its activities to suppress NF-kappa-B signaling.

Short Description: Recombinant UBA7 (UBE1L) protein was expressed in a baculovirus expression system as the full length protein (accession number NP_003326.2) with an N-terminal FLAG tag. The molecular weight of UBA7 is 112.96 kDa.

Aliases: UBE2, D8, UBA1B, UBE1L, Ubiquitin Like Modifier Activating Enzyme