SPARC Protéine

N° du produit ABIN925110

Cette protéine Native SPARC est exprimée dans .

Aperçu rapide pour SPARC Protéine (ABIN925110)

Antigène: SPARC (Secreted Protein, Acidic, Cysteine-Rich (Osteonectin) (SPARC))

Type de proteíne: Native

Origine: Boeuf (Vache)

Hôte: Veuillez nous consulter SVP

Pureté: ~ 95 %

Détail du produit

Attributs du produit: Cellular Localization: Bone, platelets, plasma (0.9 µg/mLl), serum (2.6 µg/mL).

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Supplied as solution in 0.02 M Tris, 0.15 M NaCl, pH 7.4.

Stock: -80 °C

Détail du antigène

Antigène: SPARC (Secreted Protein, Acidic, Cysteine-Rich (Osteonectin) (SPARC))

Autre désignation: Osteonectin

Sujet: Osteonectin is an acidic, noncollagenous glycoprotein originally isolated from fetal and adult bovine bone matrix. In vitro bovine bone osteonectin binds type I collagen, calcium (Kd=3x10 -7 M) and hydroxyapatite (Kd=8x10 -8 M) and has been shown to be a potent inhibitor of hydroxyapatite-seeded crystal growth. In this context it has been suggested that osteonectin may play an important role in the regulation of bone metabolism by binding hydroxyapatite to collagen. Recently, proteins homologous to osteonectin have been identified in a number of cell types, most of which are associated with extracellular matrix production. The amino acid sequence (from cDNA sequences) of one of these proteins, human placental SPARC is identical to human bone osteonectin. Osteonectin has also been identified as an alpha granule component of human platelets and is secreted during activation. A small portion of the secreted osteonectin is expressed on the platelet cell surface in an activation dependent manner. Purified platelet osteonectin is a single chain molecule which exhibits a slightly larger apparent molecular weight than that of osteonectin derived from bone. The NH2- terminal sequences of platelet- and bone- derived osteonectin are identical, but the two proteins differ with regard to the extent of glycosylation.

Poids moléculaire: 29,000 (by sedimentation equilibrium)

Pathways: Autophagy