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alpha-Thrombin Protéine

Origine: Humain Hôte: Human Native > 95 % pure Active
N° du produit ABIN934838
  • Antigène Tous les produits alpha-Thrombin
    alpha-Thrombin
    Type de proteíne
    Native
    Activité biologique
    Active
    Origine
    • 2
    • 2
    • 1
    Humain
    Source
    • 1
    • 1
    Human
    Attributs du produit
    Purified native Human alpha Thrombin protein
    Bioactivity: 4493 units/mg protein- Specific activity is determined by fibrinogen clotting assay relative to human NIH standard thrombin.
    Protein Source: Human serum/plasma
    Pureté
    > 95 % pure
  • Indications d'application
    Each Investigator should determine their own optimal working dilution for specific applications.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Supplied as a liquid with 50 % Glycerol/H2 O (vol/vol).
    Précaution d'utilisation
    Donor samples were tested and found to be negative for anti-HIV-1/2, HIV-1 antigen(s), HBsAg, STS, anti-HCV, anti-HBcore and anti-HTLV I & II. Nonetheless caution should be used when handling this material as there is a margin of error in all tests.
    Conseil sur la manipulation
    Avoid repeated freeze/thaw cycles.
    Stock
    -20 °C
    Stockage commentaire
    Aliquot and store at -20 °C.
  • Steinert, Berg, Kalinin, Jagels, Würthwein, Humpf, Kalinina: "Semisynthetic Approach toward Biologically Active Derivatives of Phenylspirodrimanes from S. chartarum." dans: ACS omega, Vol. 7, Issue 49, pp. 45215-45230, (2022) (PubMed).

    Dunker, Imberg, Siutkina, Erbacher, Daniliuc, Karst, Kalinin: "Pyrazole-Based Thrombin Inhibitors with a Serine-Trapping Mechanism of Action: Synthesis and Biological Activity." dans: Pharmaceuticals (Basel, Switzerland), Vol. 15, Issue 11, (2022) (PubMed).

    Platte, Korff, Imberg, Balicioglu, Erbacher, Will, Daniliuc, Karst, Kalinin: "Microscale Parallel Synthesis of Acylated Aminotriazoles Enabling the Development of Factor XIIa and Thrombin Inhibitors." dans: ChemMedChem, Vol. 16, Issue 24, pp. 3672-3690, (2022) (PubMed).

  • Antigène
    alpha-Thrombin
    Autre désignation
    alpha Thrombin (alpha-Thrombin Produits)
    Synonymes
    PT Protein, RPRGL2 Protein, THPH1 Protein, coagulation factor II, thrombin Protein, F2 Protein
    Sujet
    Alpha-thrombin is a highly specific serine protease generated by proteolytic activation of the zymogen prothrombin. During coagulation, thrombin cleaves fibrinogen to form fibrin, leading to the ultimate step in coagulation, the formation of a fibrin clot. Thrombin is also responsible for feedback activation of the procofactors factor V and factor VIII.
    Description: Human serum/plasma.
    Alternative Names: Thrombin alpha protein
    Poids moléculaire
    36.7 kDa
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