TPMT Protein (AA 1-245)

N° du produit ABIN934951

Détail du produit

Antigène: TPMT (Thiopurine S-Methyltransferase (TPMT))

Type de proteíne: Recombinant

Attributs du protein: AA 1-245

Origine: Humain

Source: Escherichia coli (E. coli)

Application: SDS-PAGE (SDS)

Séquence: MDGTRTSLDI EEYSDTEVQK NQVLTLEEWQ DKWVNGKTAF HQEQGHQLLK KHLDTFLKGK SGLRVFFPLC GKAVEMKWFA DRGHSVVGVE ISELGIQEFF TEQNLSYSEE PITEIPGTKV FKSSSGNISL YCCSIFDLPR TNIGKFDMIW DRGALVAINP GDRKCYADTM FSLLGKKFQY LLCVLSYDPT KHPGPPFYVP HAEIERLFGK ICNIRRLEKV DAFEERHKSW GIDCLFEKLY LLTEK

Attributs du produit: Purified recombinant Human TPMT protein
Expression System: E.coli
Molecular weight on SDS-PAGE will appear higher.

Pureté: > 95 % pure

Information d'application

Indications d'application: TPMT protein has been used in SDS PAGE and may be suitable for use in other assays to be determined by the end user.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Supplied as a liquid in 20 mM Tris, pH 8.0, containing 0.0 mM PMSF, and 0 mM EDTA.

Conseil sur la manipulation: Avoid repeated freeze/thaw cycles.

Stock: RT/-20 °C

Stockage commentaire: Store at 4 °C for short term storage (1/2 weeks). Aliquot and store at -20 °C or - 70 °C for long term storage.

Détail du antigène

Antigène: TPMT (Thiopurine S-Methyltransferase (TPMT))

Autre désignation: TPMT (TPMT Produits)

Synonymes: MGC84277 Protein, AW106912 Protein, NHLRC1 Protein, thiopurine S-methyltransferase L homeolog Protein, thiopurine S-methyltransferase, tandem duplicate 2 Protein, thiopurine S-methyltransferase TpmT Protein, thiopurine S-methyltransferase Protein, Thiopurine S-methyltransferase Protein, thiopurine methyltransferase Protein, tpmt.L Protein, tpmt.2 Protein, tpmT Protein, MCA0794 Protein, Pnap_4948 Protein, Hhal_1383 Protein, TK90_1044 Protein, Slit_1144 Protein, Tint_0842 Protein, Fbal_3334 Protein, Celly_3188 Protein, Weevi_1737 Protein, Psefu_2696 Protein, Metme_3860 Protein, Tpmt Protein, TPMT Protein

Sujet: TPMT, thiopurine S-methyltransferase, is a cytosolic enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine and azathioprine are used as chemotherapeutic agents. TPMT activity exhibits autosomal codominant genetic polymorphism, and patients inheriting TPMT-deficiency are at high risk of potentially fatal hematopoietic toxicity. Recombinant human TPMT was expressed in E. coli and purified by using conventional chromatography techniques.
Alternative Names: Thiopurine methyltransferase protein, Thiopurine S methyltransferase., Thiopurine S-methyltransferase HGNC:12014 protein, Thiopurine S-methyltransferase protein, TPMT protein, S adenosyl L methionine thiopurine S methyltransferase protein

Poids moléculaire: 28 kDa (245 AA)