CYR61 Protéine

N° du produit ABIN935294

Détail du produit

Antigène: CYR61 (Cysteine-Rich, Angiogenic Inducer, 61 (CYR61))

Type de proteíne: Recombinant

Activité biologique: Active

Origine: Humain

Source: Escherichia coli (E. coli)

Séquence: MTCPAACHCP LEAPKCAPGV GLVRDGCGCC KVCAKQLNED CSKTQPCDHT KGLECNFGAS STALKGICRA QSEGRPCEYN SRIYQNGESF QPNCKHQCTC IDGAVGCIPL CPQELSLPNL GCPNPRLVKV TGQCCEEWVC DEDSIKDPME DQDGLLGKEL GFDASEVELT RNNELIAVGK GSSLKRLPVF GMEPRILYNP LQGQKCIVQT TSWSQCSKTC GTGISTRVTN DNPECRLVKE TRICEVRPCG QPVYSSLKKG KKCSKTKKSP EPVRFTYAGC LSVKKYRPKY CGSCVDGRCC TPQLTRTVKM RFRCEDGETF SKNVMMIQSC KCNYNCPHAN EAAFPFYRLF NDIHKFRD

Attributs du produit: Purified recombinant Human CYR61 protein
Expression System: E.coli
Bioactivity: Determined by the dose-dependent stimulation of the proliferation of Mouse 3T3 cells. The expected ED50 for this effect is 2.0-3.0 µg/mL.

Pureté: > 95 % pure

niveau d'endotoxine: < 0.1 ng per µg (1 EU/µg).

Information d'application

Indications d'application: Each Investigator should determine their own optimal working dilution for specific applications.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: Supplied as a lyophilized powder.

Conseil sur la manipulation: Avoid repeated freeze/thaw cycles.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 4 °C until reconstitution. Following reconstitution aliquot and freeze at -20 °C for long term storage.

Détail du antigène

Antigène: CYR61 (Cysteine-Rich, Angiogenic Inducer, 61 (CYR61))

Autre désignation: CYR61 (CYR61 Produits)

Synonymes: CCN1 Protein, GIG1 Protein, IGFBP10 Protein, ccn1 Protein, gig1 Protein, Xcyr61 Protein, igfbp10 Protein, MGC69281 Protein, MGC69539 Protein, cyr61-l2 Protein, zgc:158158 Protein, CYR61 Protein, AI325051 Protein, Igfbp10 Protein, cysteine rich angiogenic inducer 61 Protein, cysteine-rich, angiogenic inducer, 61 Protein, cysteine-rich, angiogenic inducer, 61 like 2 Protein, cysteine rich protein 61 Protein, cysteine rich angiogenic inducer 61 S homeolog Protein, CYR61 Protein, Cyr61 Protein, cyr61 Protein, cyr61l2 Protein, cyr61.S Protein

Sujet: CYR61 is a member of the CCN family of secreted cysteine rich regulatory proteins. CYR61 induces angiogenesis by stimulating the proliferation, migration, and adhesion of endothelial cells. Cell migration and adhesion are mediated through binding to specific cell surface integrins and to heparin sulfate proteoglycans. Increased expression of CYR61 is associated with several types of cancer, and correlates with the progression and estrogen independence of human breast cancers. Recombinant human CYR61 is a 39.5 kDa protein containing 357 amino acid residues. It is composed of four distinct structural domains (modules), the IGF binding protein (IGFBP) domain, the von Willebrand Factor C (VWFC) domain, the Thrombospondin type-I (TSP type-1) domain, and a C-terminal cysteine knot-like domain (CTCK).
Alternative Names: CYR61, CYR6-1 protein, CYR-61 protein, CYR 61, CYR 61 protein, CYR-61, CCN1 protein, GIGI protein protein

Pathways: Positive Regulation of Endopeptidase Activity, Growth Factor Binding