Osteopontin Protéine

N° du produit ABIN935702

Cette protéine Recombinant Osteopontin est produite dans HEK-293T Cells.

Aperçu rapide pour Osteopontin Protéine (ABIN935702)

Antigène: Osteopontin (SPP1) (Secreted phosphoprotein 1 (SPP1))

Type de proteíne: Recombinant

Activité biologique: Active

Origine: Humain

Source: HEK-293T Cells

Pureté: > 97 % pure

Détail du produit

Séquence: IPVKQADSGS SEEKQLYNKY PDAVATWLNP DPSQKQNLLA PQNAVSSEET NDFKQETLPS KSNESHDHMD DMDDEDDDDH VDSQDSIDSN DSDDVDDTDD SHQSDESHHS DESDELVTDF PTDLPATEVF TPVVPTVDTY DGRGDSVVYG LRSKSKKFRR PDIQYPDATD EDITSHMESE ELNGAYKAIP VAQDLNAPSD WDSRGKDSYE TSQLDDQSAE THSHKQSRLY KRKANDESNE HSDVIDSQEL SKVSREFHSH EFHSHEDMLV VDPKSKEEDK HLKFRISHEL DSASSEVN

Attributs du produit: Purified recombinant Human Osteopontin protein
Expression System: 293 cells
Bioactivity: Determined by its ability to chemoattract human monocytes using a concentration range of 10.0-100.0 ng/mL.

niveau d'endotoxine: < 0.1 ng per µg (1 EU/µg).

Information d'application

Indications d'application: Each Investigator should determine their own optimal working dilution for specific applications.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Reconstitute in water to a concentration of 0.1-1.0 mg/mL.

Buffer: Supplied as a lyophilized powder.

Conseil sur la manipulation: Avoid repeated freeze/thaw cycles.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 4 °C until reconstitution. Following reconstitution aliquot and freeze at -20 °C for long term storage.

Détail du antigène

Antigène: Osteopontin (SPP1) (Secreted phosphoprotein 1 (SPP1))

Autre désignation: Osteopontin

Sujet: Osteopontin is a secreted glycoprotein that functions as a ligand to alphavbeta3 integrin and possibly other receptors. It binds tightly to hydroxyapatite and can act as a structural component of the extracellular mineralized matrix. Osteopontin is initially secreted as a 298 amino acid protein, which is subject to multiple post-translational modifications including glycosylation, phosphorylation, and specific proteolytic cleavages into various smaller molecular weight fragments. Osteopontin is expressed in a wide range of cells and tissues including osteoblasts, various tumor cell lines, extraosseous cells in the inner ear, brain, kidney, deciduum, placenta and odontoblasts. In addition to its involvement in mineralized matrix formation, Osteopontin can also function as a cytokine that stimulates the release of IFN? and IL12, while inhibiting the production of IL10.
Alternative Names: Nephropontin protein, Secreted phosphoprotein 1 protein, Uropontin protein, SPP-1 protein, Bone sialoprotein 1 protein

Poids moléculaire: 60-65 kDa

Pathways: Regulation of Cell Size