TIMP1 Protéine

N° du produit ABIN935874

Cette protéine Recombinant TIMP1 est exprimée dans Escherichia coli (E. coli).

Aperçu rapide pour TIMP1 Protéine (ABIN935874)

Antigène: TIMP1 (TIMP Metallopeptidase Inhibitor 1 (TIMP1))

Type de proteíne: Recombinant

Activité biologique: Active

Origine: Humain

Source: Escherichia coli (E. coli)

Pureté: > 95 % pure

Détail du produit

Séquence: CTCVPPHPQT AFCNSDLVIR AKFVGTPEVN QTTLYQRYEI KMTKMYKGFQ ALGDAADIRF VYTPAMESVC GYFHRSHNRS EEFLIAGKLQ DGLLHITTCS FVAPWNSLSL AQRRGFTKTY TVGCEECTVF PCLSIPCKLQ SGTHCLWTDQ LLQGSEKGFQ SRHLACLPRE PGLCTWQSLR SQIA

Attributs du produit: Purified recombinant Human TIMP1 protein
Expression System: E.coli
Bioactivity: TIMP1 activity was measured by its ability to inhibit human MMP-1 induced hydrolysis of a chromogenic peptide substrate at room temperature. Half maximal inhibition was obtained at a TIMP-1 concentration of approximately 0.5 µg/mL, when using an MMP-1 concentration of 1.6 µg/mL.

niveau d'endotoxine: < 0.1 ng per µg (1 EU/µg).

Information d'application

Indications d'application: Each Investigator should determine their own optimal working dilution for specific applications.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: Supplied as a lyophilized powder.

Conseil sur la manipulation: Avoid repeated freeze/thaw cycles.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 4 °C until reconstitution. Following reconstitution aliquot and freeze at -20 °C for long term storage.

Détail du antigène

Antigène: TIMP1 (TIMP Metallopeptidase Inhibitor 1 (TIMP1))

Autre désignation: TIMP1

Sujet: TIMP1 is an extracellular inhibitor of MMPs (see above) including MMP1, 2, 3, 7, 8, 9, 10, 11, 12, 13, and 16. It belongs to the I35 (TIMP) family of irreversible protease inhibitors that function as key modulators of extracellular matrix degradation during tissue development and remodeling. TIMP1 can also act through an MMP-independent mechanism to promote erythropoiesis by stimulating proliferation and differentiation of erythroid progenitors.
Alternative Names: TIMP 1 protein, TIMP-1 protein, TIMP-1, Tissue inhibitor of metalloproteinases: Fibroblast collagenase inhibitor, Erythroid-potentiating activity protein, TIMP1, TIMP 1, TIMP-1 protein

Poids moléculaire: 20.6 kDa