GRO gamma Protéine

N° du produit ABIN987897

Cette protéine GRO gamma est exprimée dans Escherichia coli (E. coli).

Aperçu rapide pour GRO gamma Protéine (ABIN987897)

Antigène: GRO gamma (Growth Regulated Oncogene gamma (GRO gamma))

Activité biologique: Active

Origine: Humain

Source: Escherichia coli (E. coli)

Pureté: > 97 % by SDS-PAGE and HPLC analyses.

Détail du produit

Séquence: ASVVTELRCQ CLQTLQGIHL KNIQSVNVRS PGPHCAQTEV IATLKNGKKA CLNPASPMVQ KIIEKILNKG ST

Attributs du produit: Fully biologically active when compared to standard. The ED50 determined by a chemotaxis bioassay using human CXCR2 transfected human 293 cells is less than 100 ng/ml, corresponding to a specific activity of >, 1.0 × 104 IU/mg.

niveau d'endotoxine: Level Less than 1EU/µg of rHuGRO-gamma/CXCL3 as determined by LAL method

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at < -20 °C. Further dilutions should be made in appropriate buffered solutions.

Stock: 4 °C

Détail du antigène

Antigène: GRO gamma (Growth Regulated Oncogene gamma (GRO gamma))

Autre désignation: GRO-gamma/CXCL3

Sujet: The three GRO cDNAs encode 107 amino acid precursor proteins from which the N-terminal 34 amino acid residues are cleaved to generate the mature GROs. There are no potential N-linked glycosylation sites in the amino acid sequences. GRO expression is inducible by serum or PDGF and/or by a variety of inflammatory mediators, such as IL-1 and TNF, in monocytes, fibroblasts, melanocytes and epithelial cells. In certain tumor cell lines, GRO is expressed constitutively.Similar to other alpha chemokines, the three GRO proteins are potent neutrophil attractants and activators. In addition, these chemokines are also active toward basophils. All three GROs can bind with high affinity to the IL-8 receptor type B. Synonym: GRO-gamma/CXCL3, Human. Formulation: Lyophilized from a 0.2µm filtered concentrated solution in 20mM PB, pH 7.4, 50mM NaCl.

Poids moléculaire: 7.9 kDa, a single non-glycosylated polypeptide chain containing 73 amino acids.