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IL17F Protéine

Cette protéine IL17F est exprimée dans Escherichia coli (E. coli).
N° du produit ABIN988050

Aperçu rapide pour IL17F Protéine (ABIN988050)

Antigène

Voir toutes IL17F Protéines
IL17F (Interleukin 17F (IL17F))

Activité biologique

Active

Origine

  • 15
  • 9
  • 5
  • 2
  • 1
Humain

Source

  • 14
  • 8
  • 3
  • 2
  • 2
  • 2
  • 1
Escherichia coli (E. coli)

Pureté

> 95 % by SDS-PAGE and HPLC analyses.
  • Séquence

    MRKIPKVGHT FFQKPESCPP VPGGSMKLDI GIINENQRVS MSRNIESRST SPWNYTVTWD PNRYPSEVVQ AQCRNLGCIN AQGKEDISMN SVPIQQETLV VRRKHQGCSV SFQLEKVLVT VGCTCVTPVI HHV

    Attributs du produit

    Fully biologically active when compared to standard. The ED50 determined by inducing IL-6 secretion of murine NIH/3T3 cells is less than 15 ng/ml, corresponding to a specific activity of >, 6.7 × 104 IU/mg.

    niveau d'endotoxine

    Level Less than 1EU/µg of rHuIL-17F as determined by LAL method
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  • Restrictions

    For Research Use only
  • Format

    Lyophilized

    Reconstitution

    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in 4 mM HCl to a concentration of 0.1mg/ml. Stock solutions should be apportioned into working aliquots and stored at < -20 °C. Further dilutions should be made in appropriate buffered solutions.

    Stock

    4 °C
  • Antigène

    IL17F (Interleukin 17F (IL17F))

    Autre désignation

    Interleukin-17F (IL-17F)

    Sujet

    Human IL-17F is synthesized as a 153 aa precursor with a 20 aa signal sequence and a 133 aa mature region. Like IL-17A, IL-17F contains one potential site for N-linked glycosylation. IL-17A and IL-17F share 50% aa sequence identity. IL17-F homodimer is produced by an activated subset of CD4+ T cells, termed Th17. IL17-F has been shown to stimulate proliferation and activation of T-cells and PBMCs. IL-17F also regulates cartilage matrix turnover and inhibits angiogenesis. Synonym: Interleukin-17F (IL-17F), Human. Formulation: Lyophilized from a 0.2µm filtered concentrated solution in PBS, pH 7.4.

    Poids moléculaire

    A disulfide-linked homodimer of 30.1kDa, consisting of two 134 amino acid polypeptide chains.

    Pathways

    Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Endopeptidase Activity
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