(Tyrosine-Protein Phosphatase Non-Receptor Type 22 (PTPN22))
This gene encodes of member of the non-receptor class 4 subfamily of the protein-tyrosine phosphatase family. The encoded protein is a lymphoid-specific intracellular phosphatase that associates with the molecular adapter protein CBL and may be involved in regulating CBL function in the T-cell receptor signaling pathway. Mutations in this gene may be associated with a range of autoimmune disorders including Type 1 Diabetes, rheumatoid arthritis, systemic lupus erythematosus and Graves' disease. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Mar 2009].
custom-made
PTPN22
Origine: Souris
Hôte: HEK-293 Cells
Recombinant
> 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
custom-made
PTPN22
Origine: Humain
Hôte: HEK-293 Cells
Recombinant
> 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
custom-made
PTPN22
Origine: Souris
Hôte: Cell-free protein synthesis (CFPS)
Recombinant
approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC).
WB, SDS, ELISA
custom-made
PTPN22
Origine: Humain
Hôte: Cell-free protein synthesis (CFPS)
Recombinant
approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC).
WB, SDS, ELISA
Bayley, Yang, Buckley, Young: "Measuring the specific activity of the protein tyrosine phosphatase Lyp." dans: Journal of immunological methods, Vol. 388, Issue 1-2, pp. 33-9, (2013) (PubMed).
Pseudonymes pour PTPN22 Protéines
protein tyrosine phosphatase, non-receptor type 22 (lymphoid) (Ptpn22) Protéines protein tyrosine phosphatase, non-receptor type 22 (PTPN22) Protéines protein tyrosine phosphatase, non-receptor type 22 (Ptpn22) Protéines 70zpep Protéines LYP Protéines LYP1 Protéines LYP2 Protéines PEP Protéines Ptpn8 Protéines PTPN8 Protéines