RAB family members are small, RAS-related GTP-binding proteins that are important regulators of vesicular transport. Each RAB protein targets multiple proteins that act in exocytic / endocytic pathways. This gene encodes a RAB family member that regulates vesicle traffic in the late endosomes and also from late endosomes to lysosomes. This encoded protein is also involved in the cellular vacuolation of the VacA cytotoxin of Helicobacter pylori. Mutations at highly conserved amino acid residues in this gene have caused some forms of Charcot-Marie-Tooth (CMT) type 2 neuropathies. [provided by RefSeq, Jul 2008].
Ye, Gao, Tian, Yearsley, Lange, Robertson, Barsky: "Early to intermediate steps of tumor embolic formation involve specific proteolytic processing of E-cadherin regulated by Rab7." dans: Molecular cancer research : MCR, Vol. 10, Issue 6, pp. 713-26, (2012) (PubMed).
Pseudonymes pour RAB7A Protéines
RAB5A, member RAS oncogene family (RAB5A) Protéines RAB7A, member RAS oncogene family (RAB7A) Protéines RAB7A, member RAS oncogene family (Rab7a) Protéines RAB7A, member RAS oncogene family L homeolog (rab7a.L) Protéines RAB7A, member RAS oncogene family (rab7a) Protéines rab7A protein (rab7A) Protéines RAB GTPase homolog 7A (RAB7A) Protéines Rab GTPase (rab7A) Protéines ras-related protein rab-7a (rab7a) Protéines RAB7, member RAS oncogene family (Rab7) Protéines RAB7, member RAS oncogene family (rab7) Protéines ARABIDOPSIS RAB GTPASE HOMOLOG G2 Protéines ATRAB7A Protéines ATRABG2 Protéines DDBDRAFT_0190210 Protéines DDBDRAFT_0191507 Protéines DDB_0190210 Protéines DDB_0191507 Protéines F7D8.20 Protéines F7D8_20 Protéines LOC100231734 Protéines PRO2706 Protéines pro2706 Protéines rab-7 Protéines RAB5 Protéines RAB7 Protéines Rab7 Protéines rab7 Protéines RAB7A Protéines Rab7a Protéines RAB GTPase homolog 7A Protéines zgc:64058 Protéines