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RFWD3 Protéines

(Ring Finger and WD Repeat Domain 3 (RFWD3))

E3 ubiquitin-protein ligase that mediates the ubiquitination of p53/TP53 in the late response to DNA damage, and acts as a positive regulator of p53/TP53 stability, thereby regulating the G1/S DNA damage checkpoint. May act by catalyzing the formation of short polyubiquitin chains on p53/TP53 that are not targeted to the proteasome. In response to ionizing radiation, interacts with MDM2 and enhances p53/TP53 ubiquitination, possibly by restricting MDM2 from extending polyubiquitin chains on ubiquitinated p53/TP53. Plays a role in RPA-mediated DNA damage signaling and repair.

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RFWD3 Protein (AA 1-774) (His tag)

custom-made RFWD3 Origine: Souris Hôte: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)

AlphaFold protein structure predicition of Mouse Recombinant Rfwd3 Protein, UniprotID Q8CIK8

3 images

N° du produit ABIN7564595

Détails

RFWD3 Protein (AA 1-774) (His tag)

custom-made RFWD3 Origine: Humain Hôte: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)

AlphaFold protein structure predicition of Human Recombinant RFWD3 Protein, UniprotID Q6PCD5

3 images

N° du produit ABIN7555192

Détails

RFWD3 Protein (His tag)

RFWD3 Origine: Humain Hôte: Escherichia coli (E. coli) Recombinant ELISA, SDS, WB

N° du produit ABIN7579222

Détails

RFWD3 Protein (AA 1-774) (Strep Tag)

custom-made RFWD3 Origine: Souris Hôte: Cell-free protein synthesis (CFPS) Recombinant approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC). ELISA, SDS, WB

N° du produit ABIN3136488

Détails

RFWD3 Protein (AA 1-774) (Strep Tag)

custom-made RFWD3 Origine: Humain Hôte: Cell-free protein synthesis (CFPS) Recombinant approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC). ELISA, SDS, WB

N° du produit ABIN3094992