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RHEB Produits

(Ras Homolog Enriched in Brain (RHEB))

Catégories

This gene is a member of the small GTPase superfamily and encodes a lipid-anchored, cell membrane protein with five repeats of the RAS-related GTP-binding region. This protein is vital in regulation of growth and cell cycle progression due to its role in the insulin/TOR/S6K signaling pathway. The protein has GTPase activity and shuttles between a GDP-bound form and a GTP-bound form, and farnesylation of the protein is required for this activity. Three pseudogenes have been mapped, two on chromosome 10 and one on chromosome 22. [provided by RefSeq, Jul 2008].

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Catégories RHEB en vedette

RHEB Anticorps

High quality antibodies with extensive validation data.

RHEB Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

RHEB recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Application WB, ELISA
Validations
  • (1)
  • (6)
N° du produit ABIN519784
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Human
Application ELISA, IHC
Validations
  • (2)
N° du produit ABIN7154592
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Mouse, Rat
Application WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro)
Validations
  • (2)
N° du produit ABIN704771
Quantité 100 μL
Fiche technique Fiche technique

RHEB recommandé Kits ELISA

Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
N° du produit ABIN6951226
Quantité 96 tests
Fiche technique Fiche technique

RHEB recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
N° du produit ABIN7124780
Quantité 50 μg
Fiche technique Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1317998
Quantité 10 μg
Fiche technique Fiche technique
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
  • (1)
N° du produit ABIN3127660
Quantité 1 mg
Fiche technique Fiche technique

Dernières publications sur nos produits RHEB

Ashraf, Ahn, Cha, Kim, Han, Park, Lee: "RHEB: a potential regulator of chondrocyte phenotype for cartilage tissue regeneration." dans: Journal of tissue engineering and regenerative medicine, (2016) (PubMed).

Jeon, Nam, Shin, Leem, Jeong, Jung, Bae, Jin, Kholodilov, Burke, Lee, Jin, Kim: "In vivo AAV1 transduction with hRheb(S16H) protects hippocampal neurons by BDNF production." dans: Molecular therapy : the journal of the American Society of Gene Therapy, Vol. 23, Issue 3, pp. 445-55, (2015) (PubMed).

Menon, Dibble, Talbott, Hoxhaj, Valvezan, Takahashi, Cantley, Manning: "Spatial control of the TSC complex integrates insulin and nutrient regulation of mTORC1 at the lysosome." dans: Cell, Vol. 156, Issue 4, pp. 771-85, (2014) (PubMed).

Koh, Sachidanandam, Stratman, Sacharidou, Mayo, Murphy, Cheresh, Davis: "Formation of endothelial lumens requires a coordinated PKCepsilon-, Src-, Pak- and Raf-kinase-dependent signaling cascade downstream of Cdc42 activation." dans: Journal of cell science, Vol. 122, Issue Pt 11, pp. 1812-22, (2009) (PubMed).

Sun, Fang, Yoon, Zhang, Roccio, Zwartkruis, Armstrong, Brown, Chen: "Phospholipase D1 is an effector of Rheb in the mTOR pathway." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 24, pp. 8286-91, (2008) (PubMed).

Bai, Ma, Liu, Shen, Wang, Liu, Jiang: "Rheb activates mTOR by antagonizing its endogenous inhibitor, FKBP38." dans: Science (New York, N.Y.), Vol. 318, Issue 5852, pp. 977-80, (2007) (PubMed).

Inoki, Li, Xu, Guan: "Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling." dans: Genes & development, Vol. 17, Issue 15, pp. 1829-34, (2003) (PubMed).

Stocker, Radimerski, Schindelholz, Wittwer, Belawat, Daram, Breuer, Thomas, Hafen: "Rheb is an essential regulator of S6K in controlling cell growth in Drosophila." dans: Nature cell biology, Vol. 5, Issue 6, pp. 559-65, (2003) (PubMed).

Zhang, Gao, Saucedo, Ru, Edgar, Pan: "Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins." dans: Nature cell biology, Vol. 5, Issue 6, pp. 578-81, (2003) (PubMed).

Yee, Worley: "Rheb interacts with Raf-1 kinase and may function to integrate growth factor- and protein kinase A-dependent signals." dans: Molecular and cellular biology, Vol. 17, Issue 2, pp. 921-33, (1997) (PubMed).

Synonymes et noms alternatifs relatifs à RHEB

Ras homolog, mTORC1 binding (RHEB), Ras homolog enriched in brain (Rheb), Ras homolog, mTORC1 binding (Rheb), Ras homolog enriched in brain (RHEB), Ras homolog, mTORC1 binding (rheb), ras homolog enriched in brain (rheb), Ras homolog, mTORC1 binding L homeolog (rheb.L), CG1081, Dmel\CG1081, Dm Rheb, DmRheb, DReb, dRheb, Q9VND8, RHEB, RheB, rheb, RHEB2, rheb2

Protein level used designations for RHEB

  • GTP-binding protein Rheb
  • Ras homolog enriched in brain 2
  • RAS-homolog enriched in brain
  • Ras homolog enriched in brain
  • ras homolog enriched in brain
  • GTP-binding protein rheb
  • CG1081 gene product from transcript CG1081-RA
  • CG1081-PA
  • CG1081-PB
  • RAS homolog enriched in brain
  • Ras homolog enriched in brain ortholog
  • Ras homologue enriched in brain
  • Ras homology enriched in brain
  • Rheb-PA
  • Rheb-PB
  • Ras homolog enriched in brain L homeolog
  • Ras homolog, mTORC1 binding L homeolog
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