RNF139 Produits
(Ring Finger Protein 139 (RNF139))
Catégories
The protein encoded by this gene is a multi-membrane spanning protein containing a RING-H2 finger. This protein is located in the endoplasmic reticulum, and has been shown to possess ubiquitin ligase activity. This gene was found to be interrupted by a t(3:8) translocation in a family with hereditary renal and non-medulary thyroid cancer. Studies of the Drosophila counterpart suggested that this protein may interact with tumor suppressor protein VHL, as well as with COPS5/JAB1, a protein responsible for the degradation of tumor suppressor CDKN1B/P27KIP. [provided by RefSeq, Jul 2008].
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Catégories RNF139 en vedette
RNF139 Anticorps
High quality antibodies with extensive validation data.
RNF139 Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
RNF139 recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
WB, ELISA, IHC (p)
Validations
- (1)
- (4)
N° du produit
ABIN564887
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Bat, Cow, Dog, Guinea Pig, Human, Mouse, Pig, Rabbit, Rat
Application
WB, IHC, IHC (p)
Validations
- (3)
N° du produit
ABIN6749727
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
ELISA, IHC
Validations
- (2)
N° du produit
ABIN7151154
Quantité
100 μL
Fiche technique
Fiche technique
RNF139 recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1318242
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1318244
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Insect Cells
Validations
- (1)
N° du produit
ABIN3116926
Quantité
1 mg
Fiche technique
Fiche technique
Dernières publications sur nos produits RNF139
: "TRC8 suppresses tumorigenesis through targeting heme oxygenase-1 for ubiquitination and degradation." dans: Oncogene, Vol. 32, Issue 18, pp. 2325-34, (2013) (PubMed).: "A meckelin-filamin A interaction mediates ciliogenesis." dans: Human molecular genetics, Vol. 21, Issue 6, pp. 1272-86, (2012) (PubMed).
: "The TRC8 ubiquitin ligase is sterol regulated and interacts with lipid and protein biosynthetic pathways." dans: Molecular cancer research : MCR, Vol. 8, Issue 1, pp. 93-106, (2010) (PubMed).
: "The sterol-sensing endoplasmic reticulum (ER) membrane protein TRC8 hampers ER to Golgi transport of sterol regulatory element-binding protein-2 (SREBP-2)/SREBP cleavage-activated protein and reduces ..." dans: The Journal of biological chemistry, Vol. 284, Issue 42, pp. 28995-9004, (2009) (PubMed).
: "The TRC8 E3 ligase ubiquitinates MHC class I molecules before dislocation from the ER." dans: The Journal of cell biology, Vol. 186, Issue 5, pp. 685-92, (2009) (PubMed).
: "RING-dependent tumor suppression and G2/M arrest induced by the TRC8 hereditary kidney cancer gene." dans: Oncogene, Vol. 26, Issue 16, pp. 2263-71, (2007) (PubMed).
Synonymes et noms alternatifs relatifs à RNF139
ring finger protein 139 (RNF139), ring finger protein 139 (Rnf139), ring finger protein 139 (rnf139), ring finger protein 139 S homeolog (rnf139.S), 4930555P18Rik, HRCA1, RCA1, rnf139, TRC8, zgc:175173Protein level used designations for RNF139
- E3 ubiquitin-protein ligase RNF139
- multiple membrane spanning receptor TRC8
- patched related protein translocated in renal cancer
- translocation in renal carcinoma on chromosome 8 protein
- RING finger protein 139
- ring finger protein 139 S homeolog
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