Souris anti-Humain IgM Anticorps (APC)

N° du produit ABIN371452

Aperçu rapide pour Souris anti-Humain IgM Anticorps (APC) (ABIN371452)

Antigène: IgM

Clonalité: Monoclonal

Conjugué: APC

Application: Immunofluorescence (IF)

Clone: SA-DA4

Isotype: IgG1

Détail du produit

Reactivité: Humain

Hôte: Souris

Information d'application

Indications d'application: Indirect Immunofluorescent staining of IgM+ human B lymphocytes: < / = 0.2 μg/10^6cells.

Other applications not tested.
Otimal dilutions are dependent on conditions and should be determined by the user.

Commentaires:

Excitation/Emission wavelength: 650 nm/660 nm

Restrictions: For Research Use only

Stockage

Concentration: 0.1 mg/mL

Buffer: PBS containing 0.09 % Sodium Azide as preservative and a stabilizing agent.

Agent conservateur: Sodium azide

Précaution d'utilisation: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Conseil sur la manipulation: Do not freeze!
Protect conjugated products from light.
Each reagent is stable for the period shown on the bottle label if stored as directed.
Should it contain a precipitate we recommend microcentrifugation before use.

Stock: 4 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C.

Détail du antigène

Antigène: IgM

Classe de substances: Antibody

Sujet: IgM normally constitutes about 10 % of serum immunoglobulins. IgM antibody is prominent in early immune responses to most antigens and is largely confined to plasma due to it's large size. Monomeric IgM is expressed as a membrane bound antibody on the surface of B cells and as a pentamer when secreted by plasma cells. Due to it's high valency IgM is more efficient than other isotypes is binding antigens with repeating epitopes (virus particles and red blood cells) and is more efficient than IgG in activiating the complement pathway. The gene for the mu constant region contains four domains separated by short intervening sequences. IgM measurement yields information about the body's immediate resistance and response to infection as well as information related to specific diseases. Decreased levels are associated with immune deficiency states, hereditary deficiencies, and myeloma. Increased levels can be associated with Waldenstrom's macroglobulinemia, chronic infection and hepatocellular disease.Synonyms: Human Immunoglobulin M