Recombinant Souris anti-Humain IgE Anticorps

N° du produit ABIN7072336

Aperçu rapide pour Recombinant Souris anti-Humain IgE Anticorps (ABIN7072336)

Antigène: IgE

Type d'anticorp: Recombinant Antibody

Clonalité: Monoclonal

Application: ELISA, Blocking Reagent (BR)

Clone: TES-C21

Isotype: IgG1, kappa

Détail du produit

Reactivité: Humain

Hôte: Souris

Fonction: Anti-IgE [TES-C21], Mouse IgG1, kappa

Specificité: The antibody binds specifically to IgE, an immunoglobulin isotype secreted by upon stimulation of B cells by interleukins Il-4 and IL-13. IgE provides immunity to parasites such as helminths and Plasmodium falciparum. The immunoglobulin also plays a central role in the development of Type I hypersensitivity reactions and allergic diseases such as asthma, sinusitis and food allergies. These allergic responses are triggered by the binding of IgE to the high affinity receptor FcεRI, expressed on the surface of basophils and mast cells. Binding of IgE causes cross-linking of the receptor, inducing degranulation and release of inflammatory mediators, particularly of histamine. The monoclonal antibody TES-C21 binds to secreted IgE and to IgE expressed on the surface of IgE-producing B cells, thereby inhibiting IgE binding to FcεRI and the release of histamine from mast cells. The monoclonal antibody can have diagnostic applications, such as for identifying and quantifying IgE-expressing B cells and IgE levels in serum samples, and therapeutic applications in the treatment of allergies. Furthermore, the antibody can conjugated to cytotoxic drugs and deliver them specifically to IgE-producing B cells.

Attributs du produit: This reformatted mouse antibody was made using the variable domain sequences of the original Mouse IgG format, for improved compatibility with existing reagents, assays and techniques.

Purification: Protein A affinity purified

Immunogène: Polyclonal human IgE.

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

OriginalSpeciesName: Mouse

OriginalFormat: IgG

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Détail du antigène

Antigène: IgE

Classe de substances: Antibody

Sujet: Immunoglobulin E