Recombinant Souris anti-Humain IgM (full length) Anticorps

N° du produit ABIN7878403

Aperçu rapide pour Recombinant Souris anti-Humain IgM (full length) Anticorps (ABIN7878403)

Antigène: IgM

Type d'anticorp: Recombinant Antibody

Clonalité: Monoclonal

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Classe de qualité: Carrier-free

Clone: RIGHM-1623

Isotype: IgG1, kappa

Détail du produit

Épitope: full length

Reactivité: Humain

Hôte: Souris

Fonction: Recombinant IgM Antibody (azide and preservative free)

Purification: Protein G affinity chromatography

Immunogène: Full length recombinant human IGHM protein was used as the immunogen for the recombinant IgM antibody.

Information d'application

Indications d'application: Optimal dilution of the recombinant IgM antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Agent conservateur: Azide free

Stock: 4 °C,-20 °C

Stockage commentaire: Store the recombinant IgM antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Détail du antigène

Antigène: IgM

Classe de substances: Antibody

Sujet: Recognizes a protein of 75 kDa, identified as mu heavy chain of human immunoglobulins. It does not cross-react with alpha (IgA), gamma (IgG), epsilon (IgE), or delta (IgD), heavy chains, T-cells, monocytes, granulocytes, or erythrocytes. Monomeric IgM is expressed as a membrane bound antibody on the surface of B cells and as a pentamer when secreted by plasma cells. IgM antibody is prominent in early immune responses to most antigens. Aberrant levels are associated with immune deficiency states, hereditary deficiencies, myeloma, Waldenstrom's macroglobulinemia, chronic infection and hepatocellular disease. This MAb is useful in the identification of leukemias, plasmacytomas, and certain non-Hodgkin s lymphomas. The most common feature of these malignancies is the restricted expression of a single heavy chain class. Demonstration of clonality in lymphoid infiltrates indicates that the infiltrate is clonal and therefore malignant.

UniProt: P01871