Recombinant Souris anti-Humain IgA (full length), (Heavy Chain) Anticorps

N° du produit ABIN7879397

Aperçu rapide pour Recombinant Souris anti-Humain IgA (full length), (Heavy Chain) Anticorps (ABIN7879397)

Antigène: IgA

Type d'anticorp: Recombinant Antibody

Clonalité: Monoclonal

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Classe de qualité: Carrier-free

Clone: RHISA43

Isotype: IgG1, kappa

Détail du produit

Épitope: full length, Heavy Chain

Reactivité: Humain

Hôte: Souris

Fonction: Recombinant IgA Heavy Chain Antibody (azide and preservative free)

Purification: Protein G affinity chromatography

Immunogène: Full length recombinant human IGHA protein was used as the immunogen for the human recombinant IgA Heavy Chain antibody.

Information d'application

Indications d'application: Optimal dilution of the recombinant IgA Heavy Chain antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Agent conservateur: Azide free

Stock: 4 °C,-20 °C

Stockage commentaire: Store the recombinant IgA Heavy Chain antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Détail du antigène

Antigène: IgA

Classe de substances: Antibody

Sujet: This MAb is specific to heavy chain of IgA and shows minimal cross-reaction with heavy chains of other immunoglobulins. It is reactive with all subclasses of Alpha heavy chain. Immunoglobulins are four-chain, Y-shaped, monomeric structures comprised of two identical heavy chains and two identical light chains held together through inter-chain disulfide bonds. The chains form two domains, the Fab (antigen binding) fragment and the Fc (constant) fragment. Immunoglobulin A (IgA) is the main protein of the mucosal immune system. It is generated by B-cells in gut-associated lymphoid tissues. Daily production of IgA exceeds that of any of the other immunoglobulins.IgA exists mainly in dimers but can also exist as polymers or as monomers. Dimers and polymers contain a joining (J) chain that can be bound by the polymeric immunoglobulin receptor (pIgR) for transportation of the molecule to mucosal surfaces. The most common feature of plasmacytomas, and certain non-Hodgkins lymphomas is the restricted expression of a single heavy chain class. Demonstration of clonality in lymphoid infiltrates indicates that the infiltrate is clonal and therefore malignant.

UniProt: P01876