Souris anti-Humain IgA (Heavy Chain) Anticorps (CF®488A)

N° du produit ABIN7879448

Aperçu rapide pour Souris anti-Humain IgA (Heavy Chain) Anticorps (CF®488A) (ABIN7879448)

Antigène: IgA

Clonalité: Monoclonal

Conjugué: CF®488A

Application: Flow Cytometry (FACS), Immunofluorescence (IF)

Clone: IA761

Isotype: IgG1, kappa

Détail du produit

Épitope: Heavy Chain

Reactivité: Humain

Hôte: Souris

Fonction: IgA Antibody

Purification: Protein G affinity chromatography

Immunogène: Purified human immunoglobulin alpha heavy chain was used as the immunogen for the Anti-IgA antibody.

Information d'application

Indications d'application: Optimal dilution of the IgA antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: 500 µL at 0.1 mg/mL with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store the IgA antibody at 2-8oC, protected from light.

Détail du antigène

Antigène: IgA

Classe de substances: Antibody

Sujet: This MAb is specific to heavy chain of IgA and shows minimal cross-reaction with heavy chains of other immunoglobulins. It is reactive with all subclasses of Alpha heavy chain. Immunoglobulins are four-chain, Y-shaped, monomeric structures comprised of two identical heavy chains and two identical light chains held together through inter-chain disulfide bonds. The chains form two domains, the Fab (antigen binding) fragment and the Fc (constant) fragment. Immunoglobulin A (IgA) is the main protein of the mucosal immune system. It is generated by B-cells in gut-associated lymphoid tissues. Daily production of IgA exceeds that of any of the other immunoglobulins.IgA exists mainly in dimers but can also exist as polymers or as monomers. Dimers and polymers contain a joining (J) chain that can be bound by the polymeric immunoglobulin receptor (pIgR) for transportation of the molecule to mucosal surfaces. The most common feature of plasmacytomas, and certain non-Hodgkin's lymphomas is the restricted expression of a single heavy chain class. Demonstration of clonality in lymphoid infiltrates indicates that the infiltrate is clonal and therefore malignant.

UniProt: P01876