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SHC1 Produits

(SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1))
This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011].

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Catégories SHC1 en vedette

SHC1 Anticorps

High quality antibodies with extensive validation data.

SHC1 Kits ELISA

Reliable ELISA kits for a wide range of species.

SHC1 Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

SHC1 recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human, Mouse
Application WB, ELISA, ICC, FACS
Validations
  • (6)
N° du produit ABIN5542463
Quantité 0.1 mg
Fiche technique Fiche technique
Reactivity Human
Application WB, ELISA, IF, IHC (p), PLA
Validations
  • (8)
N° du produit ABIN562866
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Human, Rat
Application WB, IHC (p), ICC, IHC (fro)
Validations
  • (8)
N° du produit ABIN3044111
Quantité 100 μg
Fiche technique Fiche technique

SHC1 recommandé Kits ELISA

Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
  • (1)
N° du produit ABIN6959459
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Human, Mouse, Rat
Analytical Method Semi-Quantitative Sandwich ELISA
Validations
  • (3)
N° du produit ABIN4889788
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Human, Mouse, Rat
Analytical Method Semi-Quantitative Sandwich ELISA
Validations
  • (2)
N° du produit ABIN4889789
Quantité 96 tests
Fiche technique Fiche technique

SHC1 recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
N° du produit ABIN7125084
Quantité 50 μg
Fiche technique Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1319932
Quantité 10 μg
Fiche technique Fiche technique
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
N° du produit ABIN7125085
Quantité 50 μg
Fiche technique Fiche technique

Dernières publications sur nos produits SHC1

Wang, Zhang, Diao, Zhang: "Protective Effects of Curcumin against Sodium Arsenite-induced Ovarian Oxidative Injury in a Mouse Model." dans: Chinese medical journal, Vol. 130, Issue 9, pp. 1026-1032, (2018) (PubMed).

Głombik, Ślusarczyk, Trojan, Chamera, Budziszewska, Lasoń, Basta-Kaim: "Regulation of insulin receptor phosphorylation in the brains of prenatally stressed rats: New insight into the benefits of antidepressant drug treatment." dans: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, Vol. 27, Issue 2, pp. 120-131, (2017) (PubMed).

Bhat, Baba, Adams, Khanday: "Role of SNTA1 in Rac1 activation, modulation of ROS generation, and migratory potential of human breast cancer cells." dans: British journal of cancer, Vol. 110, Issue 3, pp. 706-14, (2014) (PubMed).

Trnka, Burlingame et al.: "Topographic studies of the GroEL-GroES chaperonin complex by chemical cross-linking using diformyl ethynylbenzene: the power of high resolution electron transfer dissociation for determination of..." dans: Molecular & cellular proteomics : MCP, Vol. 9, Issue 10, pp. 2306-17, (2010) (PubMed).

Ursini-Siegel, Cory, Zuo, Hardy, Rexhepaj, Lam, Schade, Jirstrom, Bjur, Piccirillo, Denardo, Coussens, Brennan, Gallagher, Park, Pawson, Hallett, Muller: "Receptor tyrosine kinase signaling favors a protumorigenic state in breast cancer cells by inhibiting the adaptive immune response." dans: Cancer research, Vol. 70, Issue 20, pp. 7776-87, (2010) (PubMed).

Ranieri, Fusco, Panieri, Labate, Mele, Tesori, Ferrara, Maulucci, De Spirito, Martorana, Galeotti, Pani: "Mammalian life-span determinant p66shcA mediates obesity-induced insulin resistance." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 30, pp. 13420-5, (2010) (PubMed).

Ginés, Paoletti, Alberch: "Impaired TrkB-mediated ERK1/2 activation in huntington disease knock-in striatal cells involves reduced p52/p46 Shc expression." dans: The Journal of biological chemistry, Vol. 285, Issue 28, pp. 21537-48, (2010) (PubMed).

Ma, Liu, Wu, Terada: "p66(Shc) restrains Ras hyperactivation and suppresses metastatic behavior." dans: Oncogene, Vol. 29, Issue 41, pp. 5559-67, (2010) (PubMed).

Shi, Jin, Andres: "Src-dependent TrkA transactivation is required for pituitary adenylate cyclase-activating polypeptide 38-mediated Rit activation and neuronal differentiation." dans: Molecular biology of the cell, Vol. 21, Issue 9, pp. 1597-608, (2010) (PubMed).

Brehme, Hantschel, Colinge, Kaupe, Planyavsky, Köcher, Mechtler, Bennett, Superti-Furga: "Charting the molecular network of the drug target Bcr-Abl." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, Issue 18, pp. 7414-9, (2009) (PubMed).

Synonymes et noms alternatifs relatifs à SHC1

SHC adaptor protein 1 (SHC1), Shc1p (SHC1), squalene--hopene cyclase (shc1), SHC adaptor protein 1 (Shc1), SHC (Src homology 2 domain containing) transforming protein 1 (shc1), SHC (Src homology 2 domain containing) transforming protein 1 L homeolog (shc1.L), src homology 2 domain-containing transforming protein C1 (Shc1), p66, P66shc, p66shc, SHC, shc, Shc, SHC1, SHCA, ShcA, si:dkey-246i14.4, wu:fc10h03

Protein level used designations for SHC1

  • SHC (Src homology 2 domain containing) transforming protein 1
  • Shc1p
  • Sporulation-specific activator of Chs3p (chitin synthase III), required for the synthesis of the chitosan layer of ascospores; has similarity to Skt5p, which activates Chs3p during vegetative growth; transcriptionally induced at alkaline pH
  • squalene--hopene cyclase
  • SH2 domain protein C1
  • SHC-transforming protein 1
  • src homology 2 domain-containing-transforming protein C1
  • SHC-transforming protein 1-like
  • SHC (Src homology 2 domain-containing) transforming protein 1
  • SHC-transforming protein 3
  • SHC-transforming protein A
  • src homology 2 domain-containing transforming protein C1
  • p60Shc
  • src homology collagen
  • adaptor protein SHC
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