SRPK2 Produits
(SFRS Protein Kinase 2 (SRPK2))
Catégories
Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Promotes neuronal apoptosis by up-regulating cyclin-D1 (CCND1) expression. This is done by the phosphorylation of SRSF2, leading to the suppression of p53/TP53 phosphorylation thereby relieving the repressive effect of p53/TP53 on cyclin-D1 (CCND1) expression. Phosphorylates ACIN1, and redistributes it from the nuclear speckles to the nucleoplasm, resulting in cyclin A1 but not cyclin A2 up- regulation. Plays an essential role in splicesomal B complex formation via the phosphorylation of DDX23/PRP28.
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Catégories SRPK2 en vedette
SRPK2 Anticorps
High quality antibodies with extensive validation data.
SRPK2 Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
SRPK2 recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Dog, Human, Mouse, Rat
Application
WB, IF
Validations
- (1)
- (4)
N° du produit
ABIN968376
Quantité
50 μg
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, ELISA, IHC
Validations
- (2)
N° du produit
ABIN7170677
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human, Mouse
Application
WB, IHC (p)
Validations
- (2)
N° du produit
ABIN391795
Quantité
400 μL
Fiche technique
Fiche technique
SRPK2 recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Insect cells (Sf21)
Validations
- (2)
N° du produit
ABIN5570616
Quantité
5 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Insect cells (Sf9)
Validations
- (2)
N° du produit
ABIN5570614
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1321346
Quantité
10 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits SRPK2
: "Phosphoinositide 3-kinase signalling pathways." dans: Journal of cell science, Vol. 114, Issue Pt 8, pp. 1439-45, (2001) (PubMed).: "Oncogenic kinase signalling." dans: Nature, Vol. 411, Issue 6835, pp. 355-65, (2001) (PubMed).
: "The RET proto-oncogene in human cancers." dans: Oncogene, Vol. 19, Issue 49, pp. 5590-7, (2000) (PubMed).
: "SRPK2: a differentially expressed SR protein-specific kinase involved in mediating the interaction and localization of pre-mRNA splicing factors in mammalian cells." dans: The Journal of cell biology, Vol. 140, Issue 4, pp. 737-50, (1998) (PubMed).
Synonymes et noms alternatifs relatifs à SRPK2
SRSF protein kinase 2 (SRPK2), serine/arginine-rich protein specific kinase 2 (Srpk2), SRSF protein kinase 2 (Srpk2), SRSF protein kinase 2 (srpk2), SRSF protein kinase 2 L homeolog (srpk2.L), AW226533, AW492537, AW547358, mSRPK2, SFRSK2, sfrsk2, srpk2, srpk2-b, srpk2b, Wbp6Protein level used designations for SRPK2
- SFRS protein kinase 2
- SR protein kinase 2
- SR-protein-specific kinase 2
- serine kinase SRPK2
- serine/arginine-rich protein-specific kinase 2
- serine/arginine-rich splicing factor kinase 2
- serine/threonine-protein kinase SRPK2
- SRSF protein kinase 2
- WW domain binding protein 6
- serine/arginine-rich protein specific kinase 2
- serine/threonine-protein kinase SRPK2-like
- SFRS protein kinase 2b
- SRSF protein kinase 2 L homeolog
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