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anti-Human COMT Anticorps:
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Human Polyclonal COMT Primary Antibody pour ELISA, WB - ABIN250484
Yao, Harris, Zhang: Intrarenal dopamine attenuates deoxycorticosterone acetate/high salt-induced blood pressure elevation in part through activation of a medullary cyclooxygenase 2 pathway. dans Hypertension (Dallas, Tex. : 1979) 2009
Show all 3 Pubmed References
Human Polyclonal COMT Primary Antibody pour WB - ABIN514522
Hevir, Sinkovec, Rižner: Disturbed expression of phase I and phase II estrogen-metabolizing enzymes in endometrial cancer: lower levels of CYP1B1 and increased expression of S-COMT. dans Molecular and cellular endocrinology 2010
Human Polyclonal COMT Primary Antibody pour ELISA, WB - ABIN547726
Tunbridge, Harrison, Weinberger: Catechol-o-methyltransferase, cognition, and psychosis: Val158Met and beyond. dans Biological psychiatry 2006
Human Polyclonal COMT Primary Antibody pour IHC, IHC (p) - ABIN4299996
Hirata, Hinoda, Okayama, Suehiro, Kawamoto, Kikuno, Rabban, Chen, Dahiya: COMT polymorphisms affecting protein expression are risk factors for endometrial cancer. dans Molecular carcinogenesis 2008
Human Polyclonal COMT Primary Antibody pour ELISA, ICC - ABIN6258028
Bai, Tang, Zou, Meng, Tu, Xia, Cheng, Zhang, Yang, Mu, Wang, Qin, Lv, Cao, Qin, Jiang, Chen: m6A Demethylase FTO Regulates Dopaminergic Neurotransmission Deficits Caused by Arsenite. dans Toxicological sciences : an official journal of the Society of Toxicology 2018
Cancer pain intensity is significantly higher for G/G than A/G and A/A carriers with the human catechol-O-methyltransferase (COMT) gene Val158Met polymorphism (rs4680) in pediatric patients. In the patients treated only with morphine, the mean of total dose to reach the same pain intensity is significantly higher for G/G than A/G and A/A carriers.
This study showed that the COMT Val allele homozygosity was associated with depression and the COMT Met allele carriers were at risk for posttraumatic stress disorder.
This is the first study analyzing the affective temperament in an obese population in the context of dopaminergic genes polymorphisms, including COMT Val158Met, DRD4, and DAT1. The results of our study indicate the connection between the irritable and cyclothymic dimensions in COMT heterozygotes only.
this study found the association of the GA genotype of COMT gene with psoriasis
An interaction between the amount of hearing loss and the COMT Val(158)Met polymorphism can increase susceptibility to the clinical manifestation of tinnitus.
In this sample of adults aged 78-90 years, authors found that mild parkinsonian signs were associated with white matter hyperintensities but not with COMT genotype. However, COMT genotype did modify the association of white matter hyperintensities with mild parkinsonian signs.
The results taken together suggest that COMT genetic variability may contribute to general psychopathological symptoms in patients with Bulimia Nervosa.
these data indicate that variations in COMT val(158)met may predict the nature of WM improvement after initial and longitudinal tDCS. This contributes to our understanding of the underlying mechanism by which tDCS affects behaviour.
the results suggest a possible genetic contribution of single-nucleotide polymorphisms within the ABCB1 and COMT genes in individuals with higher levels of pain sensitivity
e COMT polymorphism, and by implication cortical dopamine degradation, influences the expression of a trans-diagnostic compulsivity phenotype, even accounting for possible confounding effects of impulsivity.
The main findings of this study were that (1) individuals with the Met/Met genotype were more likely to use opioids compared to individuals with the Val/Met genotype, and (2) individuals with the Val/Met and Met/Met genotypes used significantly greater morphine equivalent dose compared to individuals with the Val/Val genotype.
Fo/no-go reversal learning task performance did not differ between COMT genotypes when subjects were well-rested. However, total sleep deprivation exposed a significant vulnerability to adaptive decision making impairment in subjects with the Val allele.
G allele of COMT rs6269 and COMT Haplotype 6 (G_C_C_G for rs6269, rs4633, rs4818, and rs4680) are significantly associated with cognitive decline in patients with Parkinson after a follow-up period of 2 years.
COMT polymorphism is associated with colorectal cancer.
Attention-deficit hyperactivity disorder and panic disorder were associated with the Val allele for Caucasian samples. Substance-use disorder was associated with the Val allele for Asian samples. Bipolar disorder was associated with the Met allele in Asian samples. Obsessive-compulsive disorder tended to be associated with the Met allele only for males.
In human studies, the catecholOmethyl transferase (COMT) genotype affects the efficacy of opioids in acute and chronic pain under different settings, with recommendation grade B to the COMT single nucleotide polymorphism rs4680 (Val/Met).
Review study: COMT Val158/108Met functional polymorphism affects significantly the enzyme activity and consequently cognitive performance associated with altered dopamine function. The association of COMT Val158/108Met polymorphism with some cognitive domains and psychosis in Alzheimer's Disease was reported in some but not in all studies.
A female-specific haplotype (haplotype TG)-major depressive disorder vulnerability association was found.
The duration of mismatch negativity (MMN) was measured, and the COMTVal108/158Met polymorphism was detected by polymerase chain reaction-restriction fragment length polymorphism in schizophrenia patients. Individuals with schizophrenia and Met carrier status showed shorter mean latency of MMN than Val/Val individuals. MMN latency may reflect changes in cognitive function related to COMT enzyme activity.
High COMT activity genotype Val(158)Met increased the risk of CVD in depressed persons. The risk was higher in women compared to men.
These results suggest that COMT is an enzyme to maintain glucose homeostasis and 2-methoxyestradiol is a potential endogenous multi-target anti-diabetic candidate.
Miroestrol restored uterine COMT expression in beta-naphthoflavone-treated mice.
This study report that genetically driven reduction in COMT enzyme activity increased cortical thickness in the prefrontal cortex (PFC) and postero-parieto-temporal cortex of male, but not female adult mice.
COMT expression in the hippocampus was significantly reduced by high E2 replacement, implying increased catecholamine levels in the hippocampus of high E2 mice.
COMT overexpressing mice display an increase in dopamine release capacity in the striatum, suggesting increased COMT activity may affect dopamine signaling by enhancing synaptic clearance in the cortex and changes in striatal presynaptic dopamine function
These data confirm at the level of mouse working memory and human working memory-associated physiology a genetic interaction between COMT and DTNBP1.
The results of this study suggest that individual differences in COMT activity do not affect primary reinforcing effects of cocaine in mice.
Inhibition of COMT via serotonin binding contributes to pain hypersensitivity.
COMT knockout mice were more impulsive compared with wild-type littermates.
Data show that in male catechol-O-methyltransferase COMT(-/-)-mice, the total number of T-, and B-lymphocytes from spleen increased but the T-cell proliferative response decreased.
decreased COMT activity was associated with some changes in feeding microstructure in rats and mice
This study demonistrated that COMT deletion with elevated anxiety in females and suggest that this may be related to a heightened neuroendocrine response to acute stress in COMT KO mice.
COMT deficiency in virgin female mice with intact endogenous production of estradiol results in relative protection against atherosclerosis
In catechol-O-methyltransferase knock-out mice administration of tetrahydrocannabinol induced a larger increase in exploratory behavior and greater impairment in spatial working memory.
Strains with the SINE haplotype (+SINE) have greater Comt1 enzymatic activity. +SINE mice also exhibit behavioral differences in anxiety assays and decreased pain sensitivity.
Findings show that Comt1(B2i) (a B2 SINE insertion) results in a relatively modest difference in Comt1 expression and enzyme activity which has a demonstrable behavioral effect across a variety of outbred genetic backgrounds.
the source of variation in Comt
A lack of S-COMT has a notable brain-area and sex-dependent effect on the O-methylation of dopamine and 3,4-dihydroxyphenylacetic acid in the mouse brain and induces subtle change in social behavior and nociception
In the mouse, the prefrontal cortex COMT contributes about one half of the total dopamine clearance.
Both soluble COMT and membrane-bound COMT forms were abundantly found in microglial cells and intestinal macrophages, but also in astroglial cells. COMT was also present in some neuronal cells and nuclear COMT is not visible in S-COMT deficient mice.
An analysis of polymorphisms of the COMT gene as a preliminary step in evaluating the role of the gene in behavior is reported.
Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters.
, catechol-O-methyltransferase 1
, catechol O-methyltransferase, soluble form
, catechol O-methyltransferase, membrane-bound form