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anti-Human COMT Anticorps:
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Human Polyclonal COMT Primary Antibody pour ELISA, WB - ABIN250484
Yao, Harris, Zhang: Intrarenal dopamine attenuates deoxycorticosterone acetate/high salt-induced blood pressure elevation in part through activation of a medullary cyclooxygenase 2 pathway. dans Hypertension (Dallas, Tex. : 1979) 2009
Show all 3 Pubmed References
Human Polyclonal COMT Primary Antibody pour ELISA, WB - ABIN547726
Tunbridge, Harrison, Weinberger: Catechol-o-methyltransferase, cognition, and psychosis: Val158Met and beyond. dans Biological psychiatry 2006
Human Polyclonal COMT Primary Antibody pour WB - ABIN514522
Hevir, Sinkovec, Rižner: Disturbed expression of phase I and phase II estrogen-metabolizing enzymes in endometrial cancer: lower levels of CYP1B1 and increased expression of S-COMT. dans Molecular and cellular endocrinology 2010
Human Polyclonal COMT Primary Antibody pour ELISA, ICC - ABIN6258028
Bai, Tang, Zou, Meng, Tu, Xia, Cheng, Zhang, Yang, Mu, Wang, Qin, Lv, Cao, Qin, Jiang, Chen: m6A Demethylase FTO Regulates Dopaminergic Neurotransmission Deficits Caused by Arsenite. dans Toxicological sciences : an official journal of the Society of Toxicology 2018
Human Polyclonal COMT Primary Antibody pour IHC, IHC (p) - ABIN4299996
Hirata, Hinoda, Okayama, Suehiro, Kawamoto, Kikuno, Rabban, Chen, Dahiya: COMT polymorphisms affecting protein expression are risk factors for endometrial cancer. dans Molecular carcinogenesis 2008
data support the role of COMT, and particularly of rs4680, in the pathogenesis of AD. Furthermore, the SIRT1 gene seems to modulate depressive symptomatology in the AD population.
It influences enzymatic breakdown of DA.
These results indicate that executive functions such as set-shifting and working memory in Parkinson's disease are influenced by COMT gene polymorphism, while inhibition is not affected by the COMT gene polymorphism.
Study demonstrated differential cognitive change after acute antipsychotic therapy in untreated first episode patients with psychotic disorders based on COMT genotype. Met carriers showed cognitive improvement after antipsychotic treatment characterized by a significant reduction of both perseverative and regressive errors. Val homozygotes may be vulnerable to adverse effects of antipsychotic medication on cognition.
COMT Val158Met modulates long-term fear/extinction recall in late positive potential and fear bradycardia.
Neither the replicated study nor the meta-analyses indicated the 5-HTTLPR and COMT Val158Met were associated with alexithymia.
Results showed a significant interaction effect between COMT polymorphism and cannabis use on verbal fluency and speed of processing.
The study revealed that, compared with children with at least one Met allele (Met/Met and Met/Val), children who were Val homozygous (i) were more able to flexibly switch rules in cognitive shifting tasks and (ii) exhibited increased activations in lateral prefrontal regions during these tasks.
although nominally significant results did not withstand correction for multiple tests they may support a relevance of the COMT (Val158Met) and IL6 rs1800795 polymorphism for aspects of PTSD in war traumatized individuals
Our study provided evidence for the modifying effect of season of birth on the association between COMT and ADHD along with its symptoms.
No effects of COMT and estradiol on working memory performance and brain activation in healthy postmenopausal women.
This meta-analysis showed a lack of association between the BDNF 196 G/A and COMT Val158Met polymorphisms and ADHD.
Findings support the significant role of COMT in regulating behavioural intra-subject variability with its facetted structure and presumed underlying neural processes.
The Met allele of the rs6275 SNP is associated with lower COMT receptor density, resulting in less auto-regulating, pre-synaptic activity and higher dopamine signaling.The Met/Met homozygotes had greater average moderate to vigorous physical activity during the Lifestyle training interventions.
Association between the COMT polymorphism and manual dexterity asymmetry in healthy populations.
Cancer pain intensity is significantly higher for G/G than A/G and A/A carriers with the human catechol-O-methyltransferase (COMT) gene Val158Met polymorphism (rs4680) in pediatric patients. In the patients treated only with morphine, the mean of total dose to reach the same pain intensity is significantly higher for G/G than A/G and A/A carriers.
This study showed that the COMT Val allele homozygosity was associated with depression and the COMT Met allele carriers were at risk for posttraumatic stress disorder.
This is the first study analyzing the affective temperament in an obese population in the context of dopaminergic genes polymorphisms, including COMT Val158Met, DRD4, and DAT1. The results of our study indicate the connection between the irritable and cyclothymic dimensions in COMT heterozygotes only.
this study found the association of the GA genotype of COMT gene with psoriasis
An interaction between the amount of hearing loss and the COMT Val(158)Met polymorphism can increase susceptibility to the clinical manifestation of tinnitus.
These results suggest that COMT is an enzyme to maintain glucose homeostasis and 2-methoxyestradiol is a potential endogenous multi-target anti-diabetic candidate.
Miroestrol restored uterine COMT expression in beta-naphthoflavone-treated mice.
This study report that genetically driven reduction in COMT enzyme activity increased cortical thickness in the prefrontal cortex (PFC) and postero-parieto-temporal cortex of male, but not female adult mice.
COMT expression in the hippocampus was significantly reduced by high E2 replacement, implying increased catecholamine levels in the hippocampus of high E2 mice.
COMT overexpressing mice display an increase in dopamine release capacity in the striatum, suggesting increased COMT activity may affect dopamine signaling by enhancing synaptic clearance in the cortex and changes in striatal presynaptic dopamine function
These data confirm at the level of mouse working memory and human working memory-associated physiology a genetic interaction between COMT and DTNBP1.
The results of this study suggest that individual differences in COMT activity do not affect primary reinforcing effects of cocaine in mice.
Inhibition of COMT via serotonin binding contributes to pain hypersensitivity.
COMT knockout mice were more impulsive compared with wild-type littermates.
Data show that in male catechol-O-methyltransferase COMT(-/-)-mice, the total number of T-, and B-lymphocytes from spleen increased but the T-cell proliferative response decreased.
decreased COMT activity was associated with some changes in feeding microstructure in rats and mice
This study demonistrated that COMT deletion with elevated anxiety in females and suggest that this may be related to a heightened neuroendocrine response to acute stress in COMT KO mice.
COMT deficiency in virgin female mice with intact endogenous production of estradiol results in relative protection against atherosclerosis
In catechol-O-methyltransferase knock-out mice administration of tetrahydrocannabinol induced a larger increase in exploratory behavior and greater impairment in spatial working memory.
Strains with the SINE haplotype (+SINE) have greater Comt1 enzymatic activity. +SINE mice also exhibit behavioral differences in anxiety assays and decreased pain sensitivity.
Findings show that Comt1(B2i) (a B2 SINE insertion) results in a relatively modest difference in Comt1 expression and enzyme activity which has a demonstrable behavioral effect across a variety of outbred genetic backgrounds.
the source of variation in Comt
A lack of S-COMT has a notable brain-area and sex-dependent effect on the O-methylation of dopamine and 3,4-dihydroxyphenylacetic acid in the mouse brain and induces subtle change in social behavior and nociception
In the mouse, the prefrontal cortex COMT contributes about one half of the total dopamine clearance.
Both soluble COMT and membrane-bound COMT forms were abundantly found in microglial cells and intestinal macrophages, but also in astroglial cells. COMT was also present in some neuronal cells and nuclear COMT is not visible in S-COMT deficient mice.
An analysis of polymorphisms of the COMT gene as a preliminary step in evaluating the role of the gene in behavior is reported.
Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters.
, catechol-O-methyltransferase 1
, catechol O-methyltransferase, soluble form
, catechol O-methyltransferase, membrane-bound form