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The treatment of cells with EAC induced CYP1A1/1B1 mRNA and protein. The enhancement of BaP tetrol formation was inhibited by the aryl hydrocarbon receptor (AhR) inhibitor, alpha-napthoflavone, indicating EAC likely induces CYP1A1/1B1 and enhances BaP metabolism by activating the AhR.
Antagonism of AhR and knockdown of AhR and its binding partner aryl hydrocarbon receptor nuclear translocator (ARNT) attenuated CYP1A1 induction by serotonin.
We also observed ~30-fold increase in the expression of CYP1A1 at mRNA level, ~2.5-fold increase in its enzymatic activity as well as elevated ROS and cytotoxicity in U1 cells. The knock-down of the CYP1A1 gene using siRNA and treatment with selective CYP inhibitors and antioxidants significantly reduced HIV-1 replication
results suggest the polymorphic variants in the CYP1A1 gene along with GSTM1 and GSTT1 do act as a genetic modifier for lung cancer susceptibility and are strongly associated with lung cancer risk in population of North Indians; positive results in the gene-gene interactions analysis seem to indicate that these interactions play an important role with lung cancer development
To assess the complete evidence of an association between the CYP1A1 rs4646903 polymorphism and male infertility, we performed the present comprehensive meta-analysis of published studies.
A case-control study, demonstrated susceptibility of prenatal exposure to environmental tobacco smoke-related full-term low birth weight infants could be explained by the genotype combinations of CYP1A1 and GSTs genes, rather than by the attribution of a single metabolism gene. Among pregnant women without ETS exposure, genotype did not independently increase the risk of Full-term low birth weight infants.
Xenobiotic Response Elements (XREs) from Human CYP1A1 Gene Enhance the hTERT Promoter Activity.
TAG constituted by CYP1A1 T6235C and C4887A and A4889G is less common in oral cancer.
CYP1A1 SNPs are significantly associated with the risk for adenomyosis.
Combined treatment of Benzo[a]pyrene (BaP) and diallyl trisulfide (DATS) also increased reactive oxygen species levels. DATS enhanced BaP-induced AHR recruitment and histone H3 acetylation on the CYP1A1 promoter. DATS combined treatment enhances BaP metabolic activation through an aryl hydrocarbon receptor-modulating mechanism
AhR-CYP1A1 pathway has a significant role in lipid accumulation
Coffee consumption is causally associated with an increased risk of osteoarthritis. SNPs in NCALD, POR, CYP1A1 and NRCAM were identified.
CYP1A1 Polymorphism is associated with Nasopharyngeal Cancer.
The aim of this study was to investigate serum concentrations of AhR, cytochromes P450 (CYP) 1A1 and 1B1 in patients with exacerbated psoriasis vulgaris.
Overall, docetaxel plus thiotepa and docetaxel plus capecitabine result in similar clinical efficacy for metastatic breast cancer patients; however, efficacy for each therapy differs depending on CYP1A1*2C genotype
These findings suggest that Malassezia pachydermatis infection of human keratinocytes induces activation of the AhR, and increases the expression of its responsive genes, including CYP1A1.
rs1048943 of CYP1A1 is associated with cervical cancer.[review and meta-analysis]
Results indicate that the underlying mechanisms whereby etoposide and ellipticine regulate CYP1A1 expression must be different and may not be linked to p53 activation alone.
rs2470893 SNP, which maps 196 bp from a CYP1A1 promoter XRE, is associated with variations in 3MC-dependent AHR binding and CYP1A1 expression.
study demonstrates the importance of CYP1A1 gene expression as well as organochlorine pesticides levels in the context of urinary bladder cancer risk.
These results suggest that intracellular accumulation of serotonin (5-HT) via SERT induces CYP1A1 expression via AhR in intestinal epithelial cells, and SERT deficiency in vivo impairs activation of AhR.
Miroestrol suppressed beta-naphthoflavone increases in CYP1A1.
up-regulated expression during benzo(a)pyrene induced pulmonary carcinogenesis
Taken together, CAPE decreases 3-MC-mediated CYP1A1 expression, and this inhibitory response is associated with inhibition of AhR and HIF-1alpha induction.
Our results support the hypothesis that CYP1A1 protects against hyperoxic lung injury by decreasing oxidative stress.
Suggest an important role for CYP1A enzymes in the gender-specific modulation of hyperoxic lung injury.
Hypertension fails to disrupt white matter integrity in young or aged Fisher (F44) Cyp1a1Ren2 transgenic rats.
CYP1A1 contributes to nitric oxide bioavailability and blood pressure regulation mediated by dietary omega-3 polyunsaturated fatty acids.
Aryl hydrocarbon receptor mediated induction of hepatic CYP1A1/1A2 is dependent on the presence of ctnnb1.
Suggest that CYP1A induction by coplanar polychlorinated/brominated biphenyls depends on AhR transcriptional activity and not on AhR expression.
Identify hepatic proteins necessary for the AHR-dependent induction of CYP1A1 by 2,3,7,8-tetrachlorodibenzo-p-dioxin.
In livers of HRN mice Cyp1a1, cytochrome b5 and mEH can effectively activate BaP to DNA binding species, even in the presence of very low amounts of P450 oxidoreductase.
Reactive oxygen species production contributes to benzo[a]pyrene (BaP)-exacerbated atherosclerosis and CYP1A1 plays a protective role against oral BaP toxicity in aorta
harmine and harmaline are promising candidate to inhibit TCDD-mediated induction of Cyp1a1 in mice hepatic and extrahepatic tissues
Regular consumption of green and white tea exerted protection against benzo(a)pyrene induced toxicity as it modulates the CYP1B1, CYP1A1 enzymes, resulting in reduction of BaPDE-DNA adducts formation.
These data suggest that CYP1A1 metabolizes n-3 polyunsaturated fatty acids to vasodilators in vivo and the loss of these vasodilators may lead to increases in blood pressure.
the presence of ligands for TLR2 of bacterial origin seems to be crucial for detoxication of luminal carcinogens by CYP1A1 in the intestine.
Alternaria mycotoxins alternariol and alternariol methyl ether induce cytochrome P450 1A1 and apoptosis in murine hepatoma cells dependent on the aryl hydrocarbon receptor.
prolonged induction of AHR activity through inhibition of CYP1 disturbs feedback regulation of FICZ levels, with potential detrimental consequences
Signaling through beta-catenin activates basal CYP1A1 expression and augments CYP1A1 induction by aryl hydrocarbon receptor ligands through enhancement of the transactivation potential of the aryl hydrocarbon receptor.
Significant CYP1A1 expression increases over control animals was observed in ileum tissue in swine exposed to a single dose of 10 mgkg-bw-1 PAHs
There was no association between CYP1A1 C genotype and survival in the overall study population
The effect of human chorionic gonadotropin on the activities of cytochrome P-450 CYP1A1, cytochrome P-450 CYP2B1 and methoxyresorufin O-demethylase (MROD) was studied in intact male pigs of 2 breeds.[CYP2B1; MROD]
This study demonstrated for the first time that the serum testosterone level is one of the physiological factors which regulate constitutive expression of hepatic CYP1A1 and CYP1A2 in pigs.
The findings demonstrate a gender-related difference in the constitutive expression of hepatic CYP1A1 in Meishan pigs and further indicate that testosterone down-regulates the constitutive gene expression of the enzyme.
Distinct subtypes of urinary bladder epithelial cells with inducible and non-inducible cytochrome P-450 CYP1A1 are reported.
Effect of beta-napthoflavone on AHR-related gene, CYP1A1, in the pig is reported.
CYP1A1 and CYP1A2 localization into different lipid microdomains is governed by their N-terminal and internal protein regions
Hypersensitive assessment of aryl hydrocarbon receptor transcriptional activity using a novel truncated cyp1a promoter in zebrafish.
A functioning CYP1/AHR2 feedback loop is crucial for regulation of AHR2 signaling by a potential physiological ligand in vivo.
The effects of weak aryl hydrocarbon receptor agonists on zebrafish embryo heart development after inhibition of CYP1a and AHR2 knockdown are reported.
cDNA cloning; expression patterns are consistent with possible involvement in 2,3,7,8-tetrachloro-dibenzo-p-dioxin(TCDD)-induced toxicities
CYP1A1 induction in cumulus-oocyte complexes is necessary for correct proceeding of in vitro oocyte maturation in bovine and suggest a physiological role of AhR during resumption of meiosis.
This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown\; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15.
, aryl hydrocarbon hydroxylase
, cytochrome P1-450, dioxin-inducible
, cytochrome P450 1A1
, cytochrome P450 form 6
, cytochrome P450, subfamily I (aromatic compound-inducible), polypeptide 1
, cytochrome P450-C
, cytochrome P450-P1
, flavoprotein-linked monooxygenase
, xenobiotic monooxygenase
, aromatic compound inducible
, cytochrome P450 family 1 subfamily a polypeptide 2
, cytochrome P450 subfamily I, polypeptide 1
, cytochrome P450, 1a1, aromatic compound inducible
, cytochrome P450 CYP1A1
, P-450 PHPAH1
, P450 LM6
, P450 isozyme 6
, cytochrome P-450 PHPAH1
, cytochrome P450 LM6
, cytochrome P450 isozyme 6
, cytochrome P1-450
, cytochrome P450 subfamily I (aromatic compound-inducible) member A1 (C6 form c) (C6 form c)
, cytochrome P450, 1a1
, cytochrome P450, subfamily I (aromatic compound-inducible), member A1 (C6, form c) (C6, form c)
, cytochrome P450MT2
, microsomal monooxygenase
, cytochrome P450, subfamily I, polypeptide 1
, cytochrome P-450
, cytochrome P450 family 1 subfamily A member 1 L homeolog
, cytochrome P450, family 1, subfamily A, polypeptide 1