TRAF2 Produits
(TNF Receptor-Associated Factor 2 (TRAF2))
Catégories
The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from members of the TNF receptor superfamily. This protein directly interacts with TNF receptors, and forms a heterodimeric complex with TRAF1. This protein is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF1 interacts with the inhibitor-of-apoptosis proteins (IAPs), and functions as a mediator of the anti-apoptotic signals from TNF receptors. The interaction of this protein with TRADD, a TNF receptor associated apoptotic signal transducer, ensures the recruitment of IAPs for the direct inhibition of caspase activation. BIRC2/c-IAP1, an apoptosis inhibitor possessing ubiquitin ligase activity, can unbiquitinate and induce the degradation of this protein, and thus potentiate TNF-induced apoptosis. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of only one transcript has been determined. [provided by RefSeq, Jul 2008].
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Catégories TRAF2 en vedette
TRAF2 Anticorps
High quality antibodies with extensive validation data.
TRAF2 Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
TRAF2 recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
WB, IHC, IP
Validations
- (1)
- (8)
N° du produit
ABIN3021165
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Mouse
Application
WB, IHC, IP, ICC
Validations
- (6)
N° du produit
ABIN7443455
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, ELISA, IHC, ICC, FACS
Validations
- (8)
N° du produit
ABIN5542488
Quantité
0.1 mg
Fiche technique
Fiche technique
TRAF2 recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
N° du produit
ABIN7125407
Quantité
50 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1323495
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Insect Cells
Validations
- (1)
N° du produit
ABIN3095966
Quantité
1 mg
Fiche technique
Fiche technique
Dernières publications sur nos produits TRAF2
: "Combination of arsenic trioxide and Dasatinib: a new strategy to treat Philadelphia chromosome-positive acute lymphoblastic leukaemia." dans: Journal of cellular and molecular medicine, Vol. 22, Issue 3, pp. 1614-1626, (2018) (PubMed).: "MicroRNA-17 Suppresses TNF-α Signaling by Interfering with TRAF2 and cIAP2 Association in Rheumatoid Arthritis Synovial Fibroblasts." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 197, Issue 6, pp. 2219-28, (2017) (PubMed).
: "The MEKK1 PHD ubiquitinates TAB1 to activate MAPKs in response to cytokines." dans: The EMBO journal, Vol. 33, Issue 21, pp. 2581-96, (2014) (PubMed).
: "Downregulation of TRAF2 mediates NIK-induced pancreatic cancer cell proliferation and tumorigenicity." dans: PLoS ONE, Vol. 8, Issue 1, pp. e53676, (2013) (PubMed).
: "Gsdma3 is a new factor needed for TNF-?-mediated apoptosis signal pathway in mouse skin keratinocytes." dans: Histochemistry and cell biology, Vol. 138, Issue 3, pp. 385-96, (2012) (PubMed).
: "A novel dual signaling axis for NSP 5a3a induced apoptosis in head and neck carcinoma." dans: Oncotarget, Vol. 2, Issue 12, pp. 1055-74, (2012) (PubMed).
: "A water-soluble parthenolide analogue suppresses in vivo prostate cancer growth by targeting NFkappaB and generating reactive oxygen species." dans: The Prostate, Vol. 70, Issue 10, pp. 1074-86, (2010) (PubMed).
: "Expression of TNF-receptor associated factor 2 correlates with poor progression-free survival time in ABC-like primary nodal diffuse large B-cell lymphomas." dans: Histopathology, Vol. 52, Issue 5, pp. 578-84, (2008) (PubMed).
: "Effect of inositol hexakisphosphate kinase 2 on transforming growth factor beta-activated kinase 1 and NF-kappaB activation." dans: The Journal of biological chemistry, Vol. 282, Issue 21, pp. 15349-56, (2007) (PubMed).
: "TRAF2 and p38 are involved in B cells CD40-mediated APE/Ref-1 nuclear translocation: a novel pathway in B cell activation." dans: Molecular immunology, Vol. 45, Issue 1, pp. 76-86, (2007) (PubMed).
Synonymes et noms alternatifs relatifs à TRAF2
TNF-receptor-associated factor 2 (LOC661716), conjugal transfer protein TraF (traF2), TNF receptor associated factor 2 (TRAF2), TNF receptor-associated factor 2 (Traf2), Tnf receptor-associated factor 2 (Traf2), AI325259, MGC:45012, TANK, TRAP, TRAP3Protein level used designations for TRAF2
- GLEAN_07706
- conjugal transfer protein TraF
- E3 ubiquitin-protein ligase TRAF2
- tumor necrosis factor type 2 receptor associated protein 3
- tumor necrosis factor type 2 receptor-associated protein 3
- TRAF family member-associated NFKB activator
- TNF receptor-associated factor 2
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