VRK1 Produits
(Vaccinia Related Kinase 1 (VRK1))
Catégories
This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. This gene is widely expressed in human tissues and has increased expression in actively dividing cells, such as those in testis, thymus, fetal liver, and carcinomas. Its protein localizes to the nucleus and has been shown to promote the stability and nuclear accumulation of a transcriptionally active p53 molecule and, in vitro, to phosphorylate Thr18 of p53 and reduce p53 ubiquitination. This gene, therefore, may regulate cell proliferation. This protein also phosphorylates histone, casein, and the transcription factors ATF2 (activating transcription factor 2) and c-JUN. [provided by RefSeq, Jul 2008].
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Catégories VRK1 en vedette
VRK1 Anticorps
High quality antibodies with extensive validation data.
VRK1 Kits ELISA
Reliable ELISA kits for a wide range of species.
VRK1 Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
VRK1 recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
WB, ELISA, IP, IF, RNAi
Validations
- (6)
N° du produit
ABIN521352
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, ELISA, IHC, IP, IF
Validations
- (11)
N° du produit
ABIN2452161
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, ELISA, IHC
Validations
- (3)
N° du produit
ABIN7169217
Quantité
100 μL
Fiche technique
Fiche technique
VRK1 recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6960427
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
N° du produit
ABIN6730302
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Mouse
Analytical Method
Validations
N° du produit
ABIN1157429
Quantité
96 tests
Fiche technique
Fiche technique
VRK1 recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (2)
N° du produit
ABIN5569648
Quantité
5 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Insect cells (Sf9)
Validations
- (2)
N° du produit
ABIN5569649
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1325109
Quantité
10 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits VRK1
: "VRK1 regulates Cajal body dynamics and protects coilin from proteasomal degradation in cell cycle." dans: Scientific reports, Vol. 5, pp. 10543, (2015) (PubMed).: "Depletion of the protein kinase VRK1 disrupts nuclear envelope morphology and leads to BAF retention on mitotic chromosomes." dans: Molecular biology of the cell, Vol. 25, Issue 6, pp. 891-903, (2014) (PubMed).
: "Vaccinia-related kinase 1 (VRK1) confers resistance to DNA-damaging agents in human breast cancer by affecting DNA damage response." dans: Oncotarget, Vol. 5, Issue 7, pp. 1770-8, (2014) (PubMed).
: "Molecular genetic analysis of VRK1 in mammary epithelial cells: depletion slows proliferation in vitro and tumor growth and metastasis in vivo." dans: Oncogenesis, Vol. 2, pp. e48, (2013) (PubMed).
: "Rewiring of human lung cell lineage and mitotic networks in lung adenocarcinomas." dans: Nature communications, Vol. 4, pp. 1701, (2013) (PubMed).
: "Vaccinia-related kinase 1 (VRK1) is an upstream nucleosomal kinase required for the assembly of 53BP1 foci in response to ionizing radiation-induced DNA damage." dans: The Journal of biological chemistry, Vol. 287, Issue 28, pp. 23757-68, (2012) (PubMed).
: "The subcellular localization of vaccinia-related kinase-2 (VRK2) isoforms determines their different effect on p53 stability in tumour cell lines." dans: The FEBS journal, Vol. 273, Issue 11, pp. 2487-504, (2006) (PubMed).
: "Characterization of three paralogous members of the Mammalian vaccinia related kinase family." dans: The Journal of biological chemistry, Vol. 279, Issue 9, pp. 7934-46, (2004) (PubMed).
: "Kinetic properties of p53 phosphorylation by the human vaccinia-related kinase 1." dans: Archives of biochemistry and biophysics, Vol. 399, Issue 1, pp. 1-5, (2002) (PubMed).
: "The human vaccinia-related kinase 1 (VRK1) phosphorylates threonine-18 within the mdm-2 binding site of the p53 tumour suppressor protein." dans: Oncogene, Vol. 19, Issue 32, pp. 3656-64, (2000) (PubMed).
Synonymes et noms alternatifs relatifs à VRK1
vaccinia related kinase 1 L homeolog (vrk1.L), vaccinia related kinase 1 (vrk1), vaccinia related kinase 1 (VRK1), Serine/threonine-protein kinase VRK1 (vrk-1), vaccinia related kinase 1 (Vrk1), 51PK, MGC64390, MGC75762, PCH1, PCH1A, vrk1, VRK1, wu:fe16f06, zgc:56266Protein level used designations for VRK1
- vaccinia related kinase 1
- serine/threonine-protein kinase VRK1
- serine/threonine-protein kinase VRK1-like
- vaccinia virus B1R-related kinase 1
- vaccinia-related kinase 1
- serine/threonine-protein kinase 51PK
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