Lamin B2 anticorps
Aperçu rapide pour Lamin B2 anticorps (ABIN360851)
Antigène
Voir toutes Lamin B2 (LMNB2) AnticorpsReactivité
Hôte
Clonalité
Conjugué
Application
Clone
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Specificité
- Reacts with an epitope located in the C-terminal part of Lamin B2.
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Purification
- Purified
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Immunogène
- Detergent insoluble fraction of potoroo cell line PtK1.
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Isotype
- IgG1
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anti-Lamin B2 (LMNB2) antibody
LMNB2 Reactivité: Humain, Souris, Rat IHC, IF Hôte: Lapin Polyclonal unconjugated
anti-Lamin B2 (LMNB2) (AA 341-620) antibodyLMNB2 Reactivité: Humain WB, IHC, IF Hôte: Lapin Polyclonal unconjugated
anti-Lamin B2 (LMNB2) (AA 401-600) antibodyLMNB2 Reactivité: Humain WB, IHC, ELISA, ICC, FACS Hôte: Souris Monoclonal 2E2F4 unconjugated
anti-Lamin B2 (LMNB2) antibodyLMNB2 Reactivité: Humain WB, IHC, IF Hôte: Lapin Monoclonal unconjugated
anti-Lamin B2 (LMNB2) antibodyLMNB2 Reactivité: Humain WB, IHC (p), IP Hôte: Lapin Polyclonal unconjugated
anti-Lamin B2 (LMNB2) (Internal Region) antibodyLMNB2 Reactivité: Humain, Souris, Rat WB, IHC, IF, ICC Hôte: Lapin Polyclonal unconjugated
anti-Lamin B2 (LMNB2) antibodyKD Validated LMNB2 Reactivité: Humain WB, FACS Hôte: Lapin Monoclonal 23GB2605 unconjugated Recombinant Antibody
anti-Lamin B2 (LMNB2) antibodyLMNB2 Reactivité: Humain, Souris WB, IP Hôte: Souris Monoclonal 8F6-E8-F12 unconjugated
anti-Lamin B2 (LMNB2) antibodyLMNB2 Reactivité: Humain, Souris, Xenopus laevis, Hamster WB, IHC, FACS Hôte: Souris Monoclonal LN43 unconjugated
anti-Lamin B2 (LMNB2) (AA 476-504), (C-Term) antibodyLMNB2 Reactivité: Humain WB Hôte: Lapin Polyclonal RB19541 unconjugated
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Indications d'application
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Suitable for Immunocytochemistry on Frozen Sections, Immunoblotting and FlowCytometry. Recommended Dilutions: 1/100-1/200 for Flow cytometry and for Immunohistochemistry with avidin-biotinylatedhorseradish peroxidase complex (ABC) as detection reagent.1/100-1/1000 for Immunoblotting applications.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
Restrictions
- For Research Use only
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Concentration
- 1.0 mg/mL
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Buffer
- PBS with 0.09 % Sodium Azide as preservative.
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Agent conservateur
- Sodium azide
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Précaution d'utilisation
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Conseil sur la manipulation
- Avoid repeated freezing and thawing.
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Stock
- 4 °C/-20 °C
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Stockage commentaire
- Store lyophilized at 2 - 8 °C and reconstituted at -20 °C.
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- Lamin B2 (LMNB2)
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Autre désignation
- Lamin-B2 (LMNB2)
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Sujet
- An important part of the cell nucleus is formed by nuclear lamina. Nuclear lamins form a network of filaments at the nucleoplasmic site of the nuclear membrane. Two main subtypes of nuclear lamins can be distinguished, i.e. A-type lamins and B-type lamins. The A-type lamins comprise a set of three proteins arising from the same gene by alternative splicing, i.e. lamin A, lamin C and lamin Adel10, while the B-type lamins include two proteins arising from two distinct genes, i.e. lamin B1 and lamin B2. The nuclear lamins comprise a unique subclass of the intermediate filament protein family. They share a molecular domain organisation with the other intermediate filament proteins in that they are fibrous molecules that have an aminoterminal globular head, a central rod of a-helices and a carboxyterminal globular domain. Many biochemical and molecular features of lamins have been studied, but their functions remain still largely undetermined. One of the functions ascribed to the lamina is the maintenance of the structural integrity of the nucleus. Besides interactions with the nuclear membrane and other intermediate filaments, lamins interact with the nuclear chromatin. Eukaryotic chromatin is organised into loops, which are attached to the nuclear matrix. This organisation is thought to contribute to compaction of the chromatin and regulation of gene expression. Lamins, as part of the nuclear matrix, may be involved in these processes since chromatin binding sites have been detected in both A- and B-type lamins.Synonyms: LMN2, LMNB, LMNB-2, LMNB2, Lamin-B2, Nuclear Envelope Marker
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ID gène
- 84823
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NCBI Accession
- NP_116126
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UniProt
- Q03252
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Pathways
- Apoptose, Caspase Cascade in Apoptosis
Antigène
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