SLC1A2 anticorps (AA 562-574)
(4 références)Aperçu rapide pour SLC1A2 anticorps (AA 562-574) (ABIN968626)
Antigène
Voir toutes SLC1A2 AnticorpsReactivité
Hôte
Clonalité
Conjugué
Application
Clone
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Épitope
- AA 562-574
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Réactivité croisée
- Rat (Rattus)
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Attributs du produit
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1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
4. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing. -
Purification
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
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Immunogène
- Human EAAT2 aa. 562-574
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Isotype
- IgG1
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anti-Solute Carrier Family 1 (Glial High Affinity Glutamate Transporter), Member 2 (SLC1A2) (N-Term) antibody
SLC1A2 Reactivité: Humain, Rat, Souris, Boeuf (Vache), Chien, Cobaye, Cheval, Lapin, Poisson zèbre (Danio rerio), Mouton WB, IHC Hôte: Lapin Polyclonal unconjugated
anti-Solute Carrier Family 1 (Glial High Affinity Glutamate Transporter), Member 2 (SLC1A2) (AA 461-574) antibodySLC1A2 Reactivité: Rat, Souris WB, IHC, IF Hôte: Lapin Polyclonal unconjugated
anti-Solute Carrier Family 1 (Glial High Affinity Glutamate Transporter), Member 2 (SLC1A2) (Extracellular) antibodyKO Validated SLC1A2 Reactivité: Rat WB, IHC, IF, FACS, LCI, IC Hôte: Lapin Polyclonal unconjugated
anti-Solute Carrier Family 1 (Glial High Affinity Glutamate Transporter), Member 2 (SLC1A2) (AA 160-239) antibodySLC1A2 Reactivité: Humain WB, ELISA Hôte: Souris Monoclonal 1D8 unconjugated
anti-Solute Carrier Family 1 (Glial High Affinity Glutamate Transporter), Member 2 (SLC1A2) (AA 460-574) antibodySLC1A2 Reactivité: Humain WB, IHC, ELISA, IF Hôte: Lapin Polyclonal unconjugated
anti-Solute Carrier Family 1 (Glial High Affinity Glutamate Transporter), Member 2 (SLC1A2) (AA 146-161) antibodyKO Validated SLC1A2 Reactivité: Rat, Souris WB, ICC, IHC (p) Hôte: Lapin Polyclonal unconjugated
anti-Solute Carrier Family 1 (Glial High Affinity Glutamate Transporter), Member 2 (SLC1A2) (AA 467-516) antibodySLC1A2 Reactivité: Humain, Rat, Souris, Boeuf (Vache), Chien, Cobaye, Cheval, Lapin WB, IHC, IHC (p) Hôte: Lapin Polyclonal unconjugated
anti-Solute Carrier Family 1 (Glial High Affinity Glutamate Transporter), Member 2 (SLC1A2) (AA 144-193) antibodySLC1A2 Reactivité: Humain, Rat, Souris, Boeuf (Vache), Chien, Cobaye, Cheval WB, IHC, IHC (p) Hôte: Lapin Polyclonal unconjugated
anti-Solute Carrier Family 1 (Glial High Affinity Glutamate Transporter), Member 2 (SLC1A2) (C-Term) antibodySLC1A2 Reactivité: Humain, Souris WB, IHC, ICC, IHC (p) Hôte: Souris Monoclonal unconjugated
anti-Solute Carrier Family 1 (Glial High Affinity Glutamate Transporter), Member 2 (SLC1A2) antibodySLC1A2 Reactivité: Humain WB, FACS Hôte: Lapin Monoclonal 24GB2185 unconjugated Recombinant Antibody
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Commentaires
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Related Products: ABIN968545, ABIN967389
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Restrictions
- For Research Use only
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Format
- Liquid
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Concentration
- 250 μg/mL
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Buffer
- Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
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Agent conservateur
- Sodium azide
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Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Stock
- -20 °C
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Stockage commentaire
- Store undiluted at -20° C.
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: "The accessibility of a novel reentrant loop of the glutamate transporter GLT-1 is restricted by its substrate." dans: The Journal of biological chemistry, Vol. 275, Issue 13, pp. 9684-9, (2000) (PubMed).
: "Glutamate transporter GLT-1 is transiently localized on growing axons of the mouse spinal cord before establishing astrocytic expression." dans: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 18, Issue 15, pp. 5706-13, (1998) (PubMed).
: "Epilepsy and exacerbation of brain injury in mice lacking the glutamate transporter GLT-1." dans: Science (New York, N.Y.), Vol. 276, Issue 5319, pp. 1699-702, (1997) (PubMed).
: "Mouse excitatory amino acid transporter EAAT2: isolation, characterization, and proximity to neuroexcitability loci on mouse chromosome 2." dans: Genomics, Vol. 24, Issue 2, pp. 218-24, (1995) (PubMed).
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- SLC1A2 (Solute Carrier Family 1 (Glial High Affinity Glutamate Transporter), Member 2 (SLC1A2))
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Autre désignation
- EAAT2
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Sujet
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Electrogenic-coupled (Na+ and K+) glutamate transporters in nerve terminals and glial cells are essential for maintaining subtoxic levels of extracellular excitatory amino acid neurotransmitters (e.g. glutamate and aspartate). They are also important for modifying synaptic transmission through the cotransport of ions and neurotransmitters. Excitatory amino acid transporter 2 (EAAT2) has 8 alpha-helical transmembrane domains and two reentrant pore-loop-like structures whose conformation is altered during ion neurotransmitter transport. EAAT2 is primarily expressed in astrocytes in adult brain and spinal cord, however it is also found in axons during fetal development. Mice deficient in EAAT2 exhibit lethal epileptic seizures with destruction of hippocampal neurons and an increased susceptibility to cold-induced cortical injury. Such defects in glutamine transporters have also been implicated in stroke, brain trauma, Alzheimer's disease, amyotrophic lateral sclerosis, and Huntington's disease. Thus, glutamine transporters, such as EAAT2, are critical for prevention of neurotoxic brain injury and may regulate glutamatergic synaptic transmission. This antibody is routinely tested by western blot analysis.
Synonyms: Excitatory amino acid transporter 2, Glutamate transporter 1, GLT1 -
Poids moléculaire
- 66 kDa
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Pathways
- Dicarboxylic Acid Transport
Antigène
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