PTGS2 anticorps (AA 368-604)
(4 références)Aperçu rapide pour PTGS2 anticorps (AA 368-604) (ABIN967822)
Antigène
Voir toutes PTGS2 AnticorpsReactivité
Hôte
Clonalité
Conjugué
Application
Clone
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Épitope
- AA 368-604
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Réactivité croisée
- Souris, Humain, Poulet
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Attributs du produit
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1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Please refer to us for technical protocols. -
Purification
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
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Immunogène
- Rat Cox-2 aa. 368-604
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Isotype
- IgG1
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anti-Prostaglandin-Endoperoxide Synthase 2 (Prostaglandin G/H Synthase and Cyclooxygenase) (PTGS2) (AA 501-604) antibody
PTGS2 Reactivité: Humain, Souris, Rat WB, ELISA, IHC (p), IF (cc), IF (p), FACS, IHC (fro) Hôte: Lapin Polyclonal unconjugated
anti-Prostaglandin-Endoperoxide Synthase 2 (Prostaglandin G/H Synthase and Cyclooxygenase) (PTGS2) (AA 375-604) antibodyPTGS2 Reactivité: Humain WB, IHC, IF Hôte: Lapin Polyclonal unconjugated
anti-Prostaglandin-Endoperoxide Synthase 2 (Prostaglandin G/H Synthase and Cyclooxygenase) (PTGS2) (C-Term) antibodyVerified PTGS2 Reactivité: Humain, Souris WB, ELISA, IF, FACS Hôte: Chèvre Polyclonal unconjugated
anti-Prostaglandin-Endoperoxide Synthase 2 (Prostaglandin G/H Synthase and Cyclooxygenase) (PTGS2) (AA 363-391) antibodyPTGS2 Reactivité: Humain WB, IF, IHC (p) Hôte: Lapin Polyclonal RB17409 unconjugated
anti-Prostaglandin-Endoperoxide Synthase 2 (Prostaglandin G/H Synthase and Cyclooxygenase) (PTGS2) (AA 589-604), (C-Term) antibodyPTGS2 Reactivité: Humain, Souris WB, IHC Hôte: Lapin Polyclonal unconjugated
anti-Prostaglandin-Endoperoxide Synthase 2 (Prostaglandin G/H Synthase and Cyclooxygenase) (PTGS2) (AA 18-604) antibodyPTGS2 Reactivité: Humain, Souris WB, IHC, ELISA, FACS Hôte: Lapin Polyclonal unconjugated
anti-Prostaglandin-Endoperoxide Synthase 2 (Prostaglandin G/H Synthase and Cyclooxygenase) (PTGS2) (AA 1-604) antibodyPTGS2 Reactivité: Humain WB, IF Hôte: Souris Polyclonal unconjugated
anti-Prostaglandin-Endoperoxide Synthase 2 (Prostaglandin G/H Synthase and Cyclooxygenase) (PTGS2) (C-Term) antibodyPTGS2 Reactivité: Humain WB, IHC (p) Hôte: Lapin Polyclonal unconjugated
anti-Prostaglandin-Endoperoxide Synthase 2 (Prostaglandin G/H Synthase and Cyclooxygenase) (PTGS2) (AA 301-400) antibodyPTGS2 Reactivité: Humain, Souris, Rat, Mouton WB, ELISA, IHC (p), ICC, IF (cc), IF (p), IHC (fro) Hôte: Lapin Polyclonal unconjugated
anti-Prostaglandin-Endoperoxide Synthase 2 (Prostaglandin G/H Synthase and Cyclooxygenase) (PTGS2) (AA 555-604) antibodyPTGS2 Reactivité: Humain WB, IHC, ELISA, IF, IHC (p) Hôte: Lapin Polyclonal unconjugated
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Commentaires
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Related Products: ABIN968550, ABIN967389
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Restrictions
- For Research Use only
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Format
- Liquid
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Concentration
- 250 μg/mL
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Buffer
- Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
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Agent conservateur
- Sodium azide
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Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Stock
- -20 °C
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Stockage commentaire
- Store undiluted at -20°C.
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: "Increased expression of cyclooxygenase-2 protein in 4-nitroquinoline-1-oxide-induced rat tongue carcinomas and chemopreventive efficacy of a specific inhibitor, nimesulide." dans: Cancer research, Vol. 61, Issue 4, pp. 1451-6, (2001) (PubMed).
: "Human mesothelioma samples overexpress both cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (NOS2): in vitro antiproliferative effects of a COX-2 inhibitor." dans: Cancer research, Vol. 60, Issue 14, pp. 3696-700, (2000) (PubMed).
: "Cyclooxygenase-2 expression in macrophages: modulation by protein kinase C-alpha." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 165, Issue 7, pp. 3985-91, (2000) (PubMed).
: "Cloning and characterization of inducible nitric oxide synthase from mouse macrophages." dans: Science (New York, N.Y.), Vol. 256, Issue 5054, pp. 225-8, (1992) (PubMed).
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- PTGS2 (Prostaglandin-Endoperoxide Synthase 2 (Prostaglandin G/H Synthase and Cyclooxygenase) (PTGS2))
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Autre désignation
- Cox-2
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Sujet
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Cyclooxygenase (Cox) is also known as prostaglandin H synthase or PGH synthase (E.C. 1.14.99.1). It catalyzes the conversion of arachidonate to prostaglandin H2 (PGH2), the precursor of PGE2, PGF2alpha, PGD2, prostacyclin, and thromboxane A2. Cox actually has two different enzymatic activities: a cyclooxygenase that mediates the formation of PGG2 from oxygen and arachidonate and a hydroperoxidase that catalyzes a reduction of PGG2 yielding PGH2. Two Cox genes, Cox-1 and Cox-2, have been isolated in several species. A 4kb mRNA encodes the 604 amino acid Cox-2 protein. The two human Cox isoenzymes are 61% identical in amino acid composition with the active sites being highly conserved. Cox-2 mRNA and protein levels are induced by serum, lipopolysaccharides, growth factors, human chorionic gonadotropin and phorbol testers in various mammalian cell types. It has been shown that interleukin-1alpha (IL-1alpha) induces increased levels of Cox-2 mRNA and protein in human endothelial cells. The sustained increase in Cox-2 is apparently due (at least in part) to IL-1alpha increasing the stability of Cox-2 mRNA. This type of regulatory mechanism may play an important role in chronic inflammatory conditions.
Synonyms: PGHS-2, Cyclooxygenase-2 -
Poids moléculaire
- 70 kDa
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Pathways
- Brown Fat Cell Differentiation, Positive Regulation of fat Cell Differentiation
Antigène
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