PSMC2 anticorps (N-Term)
Aperçu rapide pour PSMC2 anticorps (N-Term) (ABIN501257)
Antigène
Voir toutes PSMC2 AnticorpsReactivité
Hôte
Clonalité
Conjugué
Application
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Épitope
- N-Term
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Séquence
- MPDYLGADQR KTKEDEKDDK PIRALDEGDI ALLKTYGQST YSRQIKQVED
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Homologie
- Cow: 100%, Dog: 100%, Goat: 77%, Guinea Pig: 100%, Horse: 92%, Human: 100%, Mouse: 92%, Rabbit: 100%, Rat: 100%
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Attributs du produit
- This is a rabbit polyclonal antibody against PSMC2. It was validated on Western Blot using a cell lysate as a positive control.
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Purification
- Affinity Purified
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Immunogène
- The immunogen is a synthetic peptide directed towards the N terminal region of human PSMC2
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anti-Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 2 (PSMC2) (AA 1-433) antibody
PSMC2 Reactivité: Humain WB Hôte: Lapin Polyclonal unconjugated
anti-Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 2 (PSMC2) (AA 1-160) antibodyPSMC2 Reactivité: Humain WB Hôte: Lapin Polyclonal unconjugated
anti-Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 2 (PSMC2) (AA 1-433) antibodyPSMC2 Reactivité: Humain WB, ELISA, IF Hôte: Souris Monoclonal 4C10-2C8 unconjugated
anti-Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 2 (PSMC2) antibodyPSMC2 Reactivité: Humain, Souris, Rat WB, ELISA, IHC Hôte: Lapin Polyclonal unconjugated
anti-Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 2 (PSMC2) antibodyPSMC2 Reactivité: Humain WB Hôte: Souris Monoclonal 1851CT193-4-40 unconjugated
anti-Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 2 (PSMC2) (Internal Region) antibodyPSMC2 Reactivité: Humain, Souris, Rat WB, ELISA, IHC, IF, ICC Hôte: Lapin Polyclonal unconjugated
anti-Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 2 (PSMC2) (AA 150-200) antibodyPSMC2 Reactivité: Humain, Souris WB, IP, IHC (fp) Hôte: Lapin Polyclonal unconjugated
anti-Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 2 (PSMC2) antibodyPSMC2 Reactivité: Humain, Souris, Rat WB Hôte: Lapin Polyclonal unconjugated
anti-Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 2 (PSMC2) antibodyPSMC2 Reactivité: Humain, Souris, Rat WB, ELISA Hôte: Lapin Polyclonal unconjugated
anti-Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 2 (PSMC2) (N-Term) antibodyPSMC2 Reactivité: Humain, Souris, Rat, Chien, Boeuf (Vache), Cobaye, Lapin, Singe, Porc WB Hôte: Lapin Polyclonal unconjugated
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Indications d'application
- Optimal working dilutions should be determined experimentally by the investigator.
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Commentaires
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Antigen size: 433 AA
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Restrictions
- For Research Use only
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Format
- Liquid
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Concentration
- Lot specific
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Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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Agent conservateur
- Sodium azide
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Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
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Stock
- -20 °C
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Stockage commentaire
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- PSMC2 (Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 2 (PSMC2))
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Autre désignation
- PSMC2
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Sujet
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The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex. In case of HIV-1 infection, PSMC2 is a positive modulator of Tat-mediated transactivation.The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits, 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. This subunit has been shown to interact with several of the basal transcription factors so, in addition to participation in proteasome functions, this subunit may participate in the regulation of transcription. This subunit may also compete with PSMC3 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: MGC3004, MSS1, Nbla10058, S7
Protein Interaction Partner: HUWE1, UBC, PSMD5, SPRTN, SUMO2, SHFM1, PSMD14, PSMD4, RNF2, PSMC1, CLIP1, RPS21, PSMD12, PSMD11, PSMD8, PSMD3, PSMD2, PSMD1, PSMC6, PSMC3, ADRM1, TXNL1, FBXO6, PARK2, BAG3, NOS2, SKIL, RAD23A, PCDH10, UCHL5, PSMD6, PSMD13, PSMD7, PSMC4, ZCCHC8, UFC1, MRP
Protein Size: 433 -
Poids moléculaire
- 49 kDa
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ID gène
- 5701
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NCBI Accession
- NM_002803, NP_002794
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UniProt
- P35998
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Pathways
- Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA, Ubiquitin Proteasome Pathway
Antigène
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