HARS1/Jo-1 anticorps
Aperçu rapide pour HARS1/Jo-1 anticorps (ABIN272164)
Antigène
Voir toutes HARS1/Jo-1 (HARS1) AnticorpsReactivité
Hôte
Clonalité
Conjugué
Application
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Specificité
- This antibody detects endogenous levels of HisRS protein. (region surrounding Glu492)
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Réactivité croisée (Details)
- Species reactivity (tested):Human, Mouse.
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Purification
- Affinity Chromatography using epitope-specific immunogen.
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anti-Histidyl-tRNA Synthetase (HARS1) (AA 1-96) antibody
HARS1 Reactivité: Humain WB, ELISA Hôte: Souris Monoclonal 4D4 unconjugated
anti-Histidyl-tRNA Synthetase (HARS1) (AA 1-509) antibodyHARS1 Reactivité: Humain WB, IF Hôte: Souris Polyclonal unconjugated
anti-Histidyl-tRNA Synthetase (HARS1) (AA 1-96) antibodyHARS1 Reactivité: Humain WB, ELISA, IF Hôte: Souris Monoclonal 1C8 unconjugated
anti-Histidyl-tRNA Synthetase (HARS1) (AA 1-180) antibodyHARS1 Reactivité: Humain WB, ELISA, IHC, IP Hôte: Lapin Polyclonal unconjugated
anti-Histidyl-tRNA Synthetase (HARS1) (AA 49-78), (N-Term) antibodyHARS1 Reactivité: Humain, Souris, Rat WB, IHC (p) Hôte: Lapin Polyclonal RB14816 unconjugated
anti-Histidyl-tRNA Synthetase (HARS1) antibodyHARS1 Reactivité: Humain WB, IP, ICC, FACS, DB Hôte: Souris Monoclonal HARSA6 unconjugated
anti-Histidyl-tRNA Synthetase (HARS1) (C-Term) antibodyHARS1 Reactivité: Humain, Souris, Rat WB, ELISA, IF, ICC Hôte: Lapin Polyclonal unconjugated
anti-Histidyl-tRNA Synthetase (HARS1) (AA 1-96) antibodyHARS1 Reactivité: Humain WB, ELISA Hôte: Souris Polyclonal unconjugated
anti-Histidyl-tRNA Synthetase (HARS1) (C-Term) antibodyHARS1 Reactivité: Humain WB, ELISA, IF Hôte: Lapin Polyclonal unconjugated
anti-Histidyl-tRNA Synthetase (HARS1) (C-Term) antibodyHARS1 Reactivité: Humain, Souris, Rat, Singe WB, IHC, IF Hôte: Lapin Polyclonal unconjugated
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Indications d'application
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ELISA: 1: 20000approx. 1: 40000. WB: 1: 500approx. 1: 1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
Restrictions
- For Research Use only
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Concentration
- 1.0 mg/mL
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Buffer
- Phosphate buffered saline (PBS), pH ~7.2, 15 mM Sodium Azide
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Agent conservateur
- Sodium azide
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Précaution d'utilisation
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Conseil sur la manipulation
- Avoid repeated freezing and thawing.
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Stock
- 4 °C/-20 °C
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Stockage commentaire
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- HARS1/Jo-1 (HARS1) (Histidyl-tRNA Synthetase (HARS1))
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Autre désignation
- Histidyl-tRNA Synthetase / HARS
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Sujet
- Histidyl-tRNA synthetase (HisRS, Jo-1) is an aminoacyl-tRNA synthetase that charges transfer RNAs (tRNAs) with a cognate histidine residue to produce histidyl-tRNA. Histidyl-tRNA is essential for the incorporation of histidine into proteins. Systemic autoimmune diseases lead to aminoacyl-tRNA synthetase autoantibodies that are directed against self structures. HisRS is an antigen in systemic autoimmune diseases such as rheumatic arthritis or polymyositis with associated interstitial lung disease, thrombocytopenia and Raynaud's phenomenon (vasospastic attacks that cause blood vessels to constrict). HisRS autoantibodies are unlike anti-synthetase antibodies because they bind the nonlinear, exposed epitopes on native HisRS when the enzyme is complexed to tRNA(His).Synonyms: HRS, HisRS, Histidine-tRNA ligase, JO1, Jo-1 antigen
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Poids moléculaire
- approx. 60 kDa
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ID gène
- 3035
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NCBI Accession
- NP_002100
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UniProt
- P12081
Antigène
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