HRK anticorps
Aperçu rapide pour HRK anticorps (ABIN127035)
Antigène
Voir toutes HRK AnticorpsReactivité
Hôte
Clonalité
Conjugué
Application
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Specificité
- The antibody detects Hrk fused with green fluorescent protein in crude extracts of E. coli transfected with Hrk-GFP.
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Purification
- Affinity purified
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Immunogène
- Synthetic peptide corresponding to residues surrounding amino acids 50 of human HRK.
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anti-Harakiri, BCL2 Interacting Protein (Contains Only BH3 Domain) (HRK) antibody
HRK Reactivité: Humain ELISA, IHC Hôte: Lapin Polyclonal unconjugated
anti-Harakiri, BCL2 Interacting Protein (Contains Only BH3 Domain) (HRK) (AA 15-50) antibodyHRK Reactivité: Humain, Souris WB, IHC (p) Hôte: Lapin Polyclonal RB04688 unconjugated
anti-Harakiri, BCL2 Interacting Protein (Contains Only BH3 Domain) (HRK) (Center) antibodyHRK Reactivité: Humain, Souris, Rat WB Hôte: Lapin Polyclonal unconjugated
anti-Harakiri, BCL2 Interacting Protein (Contains Only BH3 Domain) (HRK) (AA 1-50) antibodyHRK Reactivité: Souris, Rat ELISA, IF (cc), IF (p), IHC (p), IHC (fro), ICC Hôte: Lapin Polyclonal unconjugated
anti-Harakiri, BCL2 Interacting Protein (Contains Only BH3 Domain) (HRK) (N-Term) antibodyHRK Reactivité: Humain, Boeuf (Vache), Chien, Lapin, Porc WB Hôte: Lapin Polyclonal unconjugated
anti-Harakiri, BCL2 Interacting Protein (Contains Only BH3 Domain) (HRK) (N-Term) antibodyHRK Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien, Lapin WB Hôte: Lapin Polyclonal unconjugated
anti-Harakiri, BCL2 Interacting Protein (Contains Only BH3 Domain) (HRK) (BH3 Domain) antibodyHRK Reactivité: Humain, Souris WB, IHC Hôte: Lapin Polyclonal unconjugated
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Indications d'application
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Western Blot: 1 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
Restrictions
- For Research Use only
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Concentration
- 0.5 mg/mL
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Buffer
- PBS, pH 7.2, containing 50 % glycerol, 1 % BSA, 0.02 % sodium azide
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Agent conservateur
- Sodium azide
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Précaution d'utilisation
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Conseil sur la manipulation
- Avoid repeated freezing and thawing.
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Stock
- -20 °C/-80 °C
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Stockage commentaire
- Store the antibody undiluted at -20 °C or for long term storage (in aliquots) at -70 °C.
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- HRK (Harakiri, BCL2 Interacting Protein (Contains Only BH3 Domain) (HRK))
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Autre désignation
- Harakiri / HRK
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Sujet
- Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Hrk, a pro-apoptotic member of the Bcl-2 homology domain-3 (BH3) group of the Bcl-2 family of proteins, was identified as a novel protein induced during programmed neuronal death. It lacks significant homology to other Bcl-2 family members except for an 8-amino acid region that is similar to the BH3 motif of Bik. Hrk regulates apoptosis through interaction with the anti-apoptotic proteins Bcl-2 and Bcl-XL via this domain. It does not interact with the pro-apoptotic proteins Bax, Bak, or Bcl-XS. Hrk localizes to mitochondrial membranes in a pattern similar to that previously reported for Bcl-2 and Bcl-XL. Despite its predicted molecular weight, Hrk often migrates at 12-15 kDa.Synonyms: Activator of apoptosis harakiri, BH3-interacting domain-containing protein 3, BID3, Neuronal death protein DP5
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ID gène
- 8739
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NCBI Accession
- NP_003797
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UniProt
- O00198
Antigène
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