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PACSIN2 anticorps (C-Term)

Il existe 10+ publications pour ce produit. L’anticorps anti-PACSIN2 Polyclonal Lapin est utilisé pour la détection de PACSIN2 dans des échantillons de Humain et Souris. Il a été validé pour WB et IHC (p).

CSIN2 Antibody (ABIN392666 and ABIN2842164) western blot analysis in Daudi,HL-60 cell line and mouse brain,rat heart lysates (35 μg/lane). (PACSIN2 anticorps (C-Term))

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. (PACSIN2 anticorps (C-Term))

IHC (p)

Immunohistochemical analysis of raffin-embedded H. (PACSIN2 anticorps (C-Term))

IHC (p)

3 images

(10 références)

N° du produit ABIN392666

434,77 €

Plus frais de livraison 40,00 € et TVA

Destination: France

Envoi sous 14 à 17 jours ouvrables

Aperçu rapide pour PACSIN2 anticorps (C-Term) (ABIN392666)

Antigène

Voir toutes PACSIN2 Anticorps

PACSIN2 (Protein Kinase C and Casein Kinase Substrate in Neurons 2 (PACSIN2))

Reactivité

Humain, Souris

Hôte

Lapin

Clonalité

Polyclonal

Conjugué

Cet anticorp PACSIN2 est non-conjugé

Application

Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone

RB3584

Épitope
6

5

3

3

3

2

1

1

1

1
AA 342-371, C-Term

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène

This PACSIN2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 342-371 amino acids from the C-terminal region of human PACSIN2.

Isotype

Ig Fraction
anti-Protein Kinase C and Casein Kinase Substrate in Neurons 2 (PACSIN2) (AA 240-410) antibody
PACSIN2 Reactivité: Humain WB, ELISA, IHC, IF, IP Hôte: Lapin Polyclonal unconjugated

anti-Protein Kinase C and Casein Kinase Substrate in Neurons 2 (PACSIN2) (AA 368-428) antibody
PACSIN2 Reactivité: Humain WB, ELISA, IHC (p), IF Hôte: Souris Monoclonal 3D6 unconjugated

anti-Protein Kinase C and Casein Kinase Substrate in Neurons 2 (PACSIN2) antibody
PACSIN2 Reactivité: Humain WB, IHC (p) Hôte: Lapin Polyclonal unconjugated

anti-Protein Kinase C and Casein Kinase Substrate in Neurons 2 (PACSIN2) antibody
PACSIN2 Reactivité: Humain, Souris WB, IHC, IF/ICC Hôte: Lapin Polyclonal unconjugated

anti-Protein Kinase C and Casein Kinase Substrate in Neurons 2 (PACSIN2) (AA 342-371) antibody
PACSIN2 Reactivité: Humain, Souris WB, IHC (p), IF Hôte: Lapin Polyclonal unconjugated

anti-Protein Kinase C and Casein Kinase Substrate in Neurons 2 (PACSIN2) (AA 250-486) antibody
PACSIN2 Reactivité: Humain, Souris WB Hôte: Souris Monoclonal 1735CT116-76-60 unconjugated

anti-Protein Kinase C and Casein Kinase Substrate in Neurons 2 (PACSIN2) (AA 1-486) antibody
PACSIN2 Reactivité: Humain WB Hôte: Souris Polyclonal unconjugated

anti-Protein Kinase C and Casein Kinase Substrate in Neurons 2 (PACSIN2) (AA 1-486) antibody
PACSIN2 Reactivité: Humain WB Hôte: Lapin Polyclonal unconjugated

anti-Protein Kinase C and Casein Kinase Substrate in Neurons 2 (PACSIN2) (C-Term) antibody
PACSIN2 Reactivité: Humain, Souris WB, IHC (p), IF, EIA Hôte: Lapin Polyclonal unconjugated

anti-Protein Kinase C and Casein Kinase Substrate in Neurons 2 (PACSIN2) (AA 250-486) antibody
PACSIN2 Reactivité: Humain WB Hôte: Souris Monoclonal H5F12 unconjugated

Indications d'application

WB: 1:1000. IHC-P: 1:25. IHC-P: 1:50~100

Restrictions

For Research Use only
Format

Liquid

Buffer

Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur

Sodium azide

Précaution d'utilisation

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock

4 °C,-20 °C

Stockage commentaire

Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption

6 months
Copeland, Han, Tiwari, Austin, Loyd, West, Kenworthy: "A disease-associated frameshift mutation in caveolin-1 disrupts caveolae formation and function through introduction of a de novo ER retention signal." dans: Molecular biology of the cell, Vol. 28, Issue 22, pp. 3095-3111, (2018) (PubMed).

Han, Copeland, Kawano, Rosenzweig, Austin, Shahmirzadi, Tang, Raghunathan, Chung, Kenworthy: "Characterization of a caveolin-1 mutation associated with both pulmonary arterial hypertension and congenital generalized lipodystrophy." dans: Traffic (Copenhagen, Denmark), Vol. 17, Issue 12, pp. 1297-1312, (2017) (PubMed).

Chandrasekaran, Kenworthy, Lacy: "Clostridium difficile Toxin A Undergoes Clathrin-Independent, PACSIN2-Dependent Endocytosis." dans: PLoS pathogens, Vol. 12, Issue 12, pp. e1006070, (2017) (PubMed).

Bhattacharyya, Rainey, Arya, Mohapatra, Mushtaq, Dutta, George, Storck, McComb, Muirhead, Todd, Gould, Datta, Gelineau-van Waes, Band, Band: "Endocytic recycling protein EHD1 regulates primary cilia morphogenesis and SHH signaling during neural tube development." dans: Scientific reports, Vol. 6, pp. 20727, (2016) (PubMed).

Bahl, Xie, Spagnol, Sorgen, Naslavsky, Caplan et al.: "EHD3 Protein Is Required for Tubular Recycling Endosome Stabilization, and an Asparagine-Glutamic Acid Residue Pair within Its Eps15 Homology (EH) Domain Dictates Its Selective Binding to NPF ..." dans: The Journal of biological chemistry, Vol. 291, Issue 26, pp. 13465-78, (2016) (PubMed).

Cai, Giridharan, Zhang, Saxena, Bahl, Schmidt, Sorgen, Guo, Naslavsky, Caplan: "Differential roles of C-terminal Eps15 homology domain proteins as vesiculators and tubulators of recycling endosomes." dans: The Journal of biological chemistry, Vol. 288, Issue 42, pp. 30172-80, (2013) (PubMed).

Giridharan, Cai, Vitale, Naslavsky, Caplan: "Cooperation of MICAL-L1, syndapin2, and phosphatidic acid in tubular recycling endosome biogenesis." dans: Molecular biology of the cell, Vol. 24, Issue 11, pp. 1776-90, S1-15, (2013) (PubMed).

de Kreuk, Anthony, Geerts, Hordijk: "The F-BAR protein PACSIN2 regulates epidermal growth factor receptor internalization." dans: The Journal of biological chemistry, Vol. 287, Issue 52, pp. 43438-53, (2012) (PubMed).

Hansen, Howard, Nichols: "Pacsin 2 is recruited to caveolae and functions in caveolar biogenesis." dans: Journal of cell science, Vol. 124, Issue Pt 16, pp. 2777-85, (2011) (PubMed).

de Kreuk, Nethe, Fernandez-Borja, Anthony, Hensbergen, Deelder, Plomann, Hordijk: "The F-BAR domain protein PACSIN2 associates with Rac1 and regulates cell spreading and migration." dans: Journal of cell science, Vol. 124, Issue Pt 14, pp. 2375-88, (2011) (PubMed).
Antigène

PACSIN2 (Protein Kinase C and Casein Kinase Substrate in Neurons 2 (PACSIN2))

Autre désignation

PACSIN2

Sujet

PACSIN may play a role in vesicle formation and transport. This protein homo- and hetero-aggregates with other PACSINs. It also binds dynamin 1, synaptojanin, synapsin 1 and the neural Wiskott-Aldrich syndrome protein (N-WASP). The protein exhibits a cvesicle-like cytoplasmic distribution and is ubiquitously expressed. PACSIN is phosphorylated by casein kinase 2 (CK2) and protein kinase C (PKC). The protein contains 1 FCH domain and 1 SH3 domain.

Poids moléculaire

55739

ID gène

11252

NCBI Accession

NP_001171899, NP_001171900, NP_009160

UniProt

Q9UNF0