POLA1 anticorps
Aperçu rapide pour POLA1 anticorps (ABIN272161)
Antigène
Voir toutes POLA1 AnticorpsReactivité
Hôte
Clonalité
Conjugué
Application
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Specificité
- This antibody detects endogenous levels of DNA pol α protein. (region surrounding Lys111)
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Réactivité croisée (Details)
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Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human. -
Purification
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
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Pureté
- > 95 % pure by SDS-PAGE
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anti-DNA Polymerase alpha (POLA1) (AA 1363-1462) antibody
POLA1 Reactivité: Humain WB, ELISA Hôte: Souris Monoclonal 3C11 unconjugated
anti-DNA Polymerase alpha (POLA1) (AA 1406-1439) antibodyPOLA1 Reactivité: Souris WB, FACS Hôte: Lapin Polyclonal RB57637 unconjugated
anti-DNA Polymerase alpha (POLA1) (N-Term) antibodyPOLA1 Reactivité: Humain, Souris, Rat WB, ELISA, IHC, ICC, IF Hôte: Lapin Polyclonal unconjugated
anti-DNA Polymerase alpha (POLA1) (N-Term) antibodyPOLA1 Reactivité: Humain WB, ELISA, ICC, IF Hôte: Lapin Polyclonal unconjugated
anti-DNA Polymerase alpha (POLA1) (AA 1240-1462) antibodyPOLA1 Reactivité: Humain WB, IP, IHC, ICC Hôte: Lapin Polyclonal unconjugated
anti-DNA Polymerase alpha (POLA1) (AA 1-33) antibodyPOLA1 Reactivité: Humain WB Hôte: Lapin Polyclonal RB57636 unconjugated
anti-DNA Polymerase alpha (POLA1) (AA 1363-1462) antibodyPOLA1 Reactivité: Humain WB, ELISA Hôte: Souris Polyclonal unconjugated
anti-DNA Polymerase alpha (POLA1) (AA 310-832) antibodyPOLA1 Reactivité: Thermus aquaticus WB, ELISA Hôte: Lapin Polyclonal unconjugated
anti-DNA Polymerase alpha (POLA1) (N-Term) antibodyPOLA1 Reactivité: Humain WB, ELISA Hôte: Lapin Polyclonal unconjugated
anti-DNA Polymerase alpha (POLA1) (AA 1209-1465) antibodyPOLA1 Reactivité: Souris WB, IP, IHC, ICC Hôte: Lapin Polyclonal unconjugated
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Indications d'application
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ELISA: 1: 20000approx. 1: 40000. WB: 1: 500approx. 1: 1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
Restrictions
- For Research Use only
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Concentration
- 1,0 mg/mL
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Buffer
- Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide
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Agent conservateur
- Sodium azide
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Précaution d'utilisation
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Conseil sur la manipulation
- DO NOT FREEZE!
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Stock
- 4 °C
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Stockage commentaire
- Store the antibody undiluted at 2-8 °C.
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- POLA1 (DNA Polymerase alpha (POLA1))
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Autre désignation
- POLA1
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Sujet
- DNA replication, recombination and repair, all of which are necessary for genomic stability, require the presence of exonucleases. In DNA replication, these enzymes are involved in the processing of Okazaki fragments, whereas in DNA repair they function to excise damaged DNA fragments and correct recombinational mismatches. These exonucleases include the family of DNA polymerases. DNA pol α, β, δ and ε are involved in DNA replication and repair. DNA pol δ and DNA pol ε are multisubunit enzymes, with DNA pol δ consisting of two subunits: p125, which interacts with the sliding DNA clamp protein PCNA, and p50. The nuclear-encoded DNA pol γ is the only DNA polymerase required for the replication of the mitochondrial DNA. DNA pol ζ is ubiquitously expressed in various tissues and mediates the cellular mechanism of damage-induced mutagenesis. DNA pol θ is a DNA polymerase-helicase that binds ATP and is involved in the repair of interstrand crosslinks.Synonyms: DNA polymerase alpha catalytic subunit, DNA polymerase alpha catalytic subunit p180
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Poids moléculaire
- approx. 165 kDa
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ID gène
- 5422
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NCBI Accession
- NP_058633
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UniProt
- P09884
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Pathways
- SARS-CoV-2 Protein Interactome
Antigène
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