ITGA4 anticorps (FITC)
Aperçu rapide pour ITGA4 anticorps (FITC) (ABIN118225)
Antigène
Voir toutes ITGA4 AnticorpsReactivité
Hôte
Clonalité
Conjugué
Application
Clone
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Specificité
- This antibody recognises murine alpha 4 integrin (CD49d). Clone PS/2 has also been reported to block the binding of CD49d to its ligands. We recommend the use of SM037LE for this purpose.
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Purification
- Affinity chromatography on Protein G.
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Isotype
- IgG2b
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anti-Integrin alpha 4 (ITGA4) (Internal Region) antibody
ITGA4 Reactivité: Humain, Souris, Rat WB, ELISA, IHC (p) Hôte: Lapin Polyclonal unconjugated
anti-Integrin alpha 4 (ITGA4) antibodyITGA4 Reactivité: Humain FACS, WB, ELISA Hôte: Souris Monoclonal 5C4 unconjugated
anti-Integrin alpha 4 (ITGA4) (AA 551-650) antibodyITGA4 Reactivité: Humain, Souris, Lapin FACS, WB, ELISA, IHC (p) Hôte: Lapin Polyclonal unconjugated
anti-Integrin alpha 4 (ITGA4) (AA 833-977) antibodyITGA4 Reactivité: Humain FACS, WB, ELISA Hôte: Souris Monoclonal 7E4C5 unconjugated
anti-Integrin alpha 4 (ITGA4) (AA 376-558) antibodyITGA4 Reactivité: Humain IHC, ELISA, IF Hôte: Lapin Polyclonal unconjugated
anti-Integrin alpha 4 (ITGA4) (C-Term) antibodyITGA4 Reactivité: Humain WB, IHC Hôte: Lapin Polyclonal unconjugated
anti-Integrin alpha 4 (ITGA4) antibodyITGA4 Reactivité: Humain WB, IHC, IP Hôte: Lapin Monoclonal unconjugated
anti-Integrin alpha 4 (ITGA4) antibodyKO Validated ITGA4 Reactivité: Humain FACS, WB Hôte: Lapin Monoclonal 25GB2175 unconjugated Recombinant Antibody
anti-Integrin alpha 4 (ITGA4) antibodyITGA4 Reactivité: Humain FACS, WB, EIA Hôte: Souris Monoclonal 5C4 unconjugated
anti-Integrin alpha 4 (ITGA4) (AA 999-1028), (C-Term) antibodyITGA4 Reactivité: Humain, Rat FACS, WB, IHC, IHC (fro) Hôte: Lapin Polyclonal unconjugated
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Indications d'application
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Flow Cytometry: Use 10 μL of 1/5-1/10 diluted antibody to label 10^6 cells in 100 μL. The Fc region of monoclonal antibodies may bind non-specifically to cells expressing low affinity Fc receptors.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
Restrictions
- For Research Use only
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Concentration
- 0.1 mg/mL
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Buffer
- PBS, pH 7.4 containing 0.09 % Sodium Azide as preservative and 1 % BSA as stabilizer.
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Agent conservateur
- Sodium azide
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Précaution d'utilisation
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Conseil sur la manipulation
- Avoid repeated freezing and thawing. This product is photosensitive and should be protected from light.
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Stock
- 4 °C/-20 °C
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Stockage commentaire
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- ITGA4 (Integrin alpha 4 (ITGA4))
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Autre désignation
- CD49d / ITGA4
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Sujet
- Integrin α4 (also called CD49d) is a ~150 kDa protein that possesses a large extracellular domain involved in ligand binding, a single transmembrane domain, and an intracellular regulatory domain possessing multiple sites for phosphorylation. Integrin α4 forms heterodimers with integrins β1 and β7. Integrin α4 is expressed on leukocytes and leukocyte precursors, neural crest cells, and developing skeletal muscles and is essential for embryogenesis, hematopoiesis, and immune responses. The presence of integrin α4 promotes cell migration and inhibits cell spreading and contractility. Integrin α4 function has been implicated in the pathogenesis of multiple diseases including asthma, rheumatoid arthritis, Crohn's disease, ulcerative colitis, hepatitis C, and multiple sclerosis, and therefore, modulation of integrin α4 function has become an important target for drug discovery. Phosphorylation of the serine 988 residue on the integrin α4 cytoplasmic tail inhibits its interaction with the focal adhesion complex-associated protein paxillin, and modulates its effects on cell motility and spreading.Synonyms: CD49 antigen-like family member D, Integrin alpha-4, Integrin alpha-IV, VLA-4, VLA4
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ID gène
- 3676
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NCBI Accession
- NP_000876
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UniProt
- P13612
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Pathways
- Integrin Complex
Antigène
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