Il existe 2+ publications pour ce produit.
L’anticorps anti-VCAM1 Monoclonal Rat est utilisé pour la détection de VCAM1 dans des échantillons de Souris. Il a été validé pour WB, FACS, IP, IHC (fro), BR et Adh Act.
Low Endotoxin/Azide Free Anti-Mouse CD106 antibody for use in flow cytometry, immunohistochemistry, western blotting, immunoprecipitation, blocking, and adhesion assays.
VCAM1
Reactivité: Rat
WB, IHC, IP, ICC
Hôte: Lapin
Polyclonal
unconjugated
Indications d'application
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Format
Liquid
Concentration
0.5 mg/mL
Buffer
Phosphate buffered saline, pH 7.4
Agent conservateur
Azide free
Conseil sur la manipulation
Each reagent is stable for the period shown on the bottle label if stored as directed.
Stock
4 °C
Stockage commentaire
2-8°C
Gilchrist, Kinchesh, Zarghami, Khrapitchev, Sibson, Kersemans, Smart: "Improved detection of molecularly targeted iron oxide particles in mouse brain using B0 field stabilised high resolution MRI." dans: Magnetic resonance imaging, Vol. 67, pp. 101-108, (2020) (PubMed).
Zarghami, Khrapitchev, Perez-Balderas, Soto, Larkin, Bau, Sibson: "Optimization of molecularly targeted MRI in the brain: empirical comparison of sequences and particles." dans: International journal of nanomedicine, Vol. 13, pp. 4345-4359, (2018) (PubMed).
Antigène
VCAM1
(Vascular Cell Adhesion Molecule 1 (VCAM1))
Autre désignation
CD106
Sujet
VCAM-1 is an adhesion molecule and a major mediator of the inflammatory response. It is expressed on activated microvascular endothelial cells in response to signals arising from immune responses in infection, graft rejection, tumor recognition and killing. The complementary binding ligand for VCAM-1 is VLA-4/CD49d. In addition to VCAM-1, VLA-4 also recognizes the extracellular matrix molecule fibronectin. This pairing of VCAM-1 and VLA-4 is able to provide a second signal (i.e., non-antigen specific) for T cell stimulation, such as that seen in transplantation. The monoclonal antibody MK-2 has been used in transplant studies to suppress cardiac rejection and induce long-term cardiac graft survival. In addition to inflammatory responses, VCAM-1 has a significant role in hemopoiesis through its ability to retain lymphocyte and myeloid precursors on stromal cells in the marrow and lymphoid organs. CD106/VCAM-1 exists as an integral membrane protein.